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Immunoglobulin levels in workers exposed to hexachlorobenzene.

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      Abstract

      The serum immunoglobulin (IgG, IgM and IgA) concentrations of 52 chlorinated-exposed workers were examined and compared with those of non-exposed, age- and sex-matched individuals. At the time of testing, the exposed population had mean hexachlorobenzene (HCB) blood levels of 3.84 micrograms/dl with a range of 0.1 to 16 micrograms/dl. Increased IgG and IgM levels were found in the HCB-exposed workers (P < 0.05 and P < 0.01, respectively). Hepatic function was evaluated by serum aspartate (AST) and alanine aminotransferase (ALT) activities, as well as by bilirubin levels. IgM concentrations were positively correlated with three of the studied parameters, namely, length of exposure (r = 0.367) and the activities of both AST (r = 0.367) and ALT (r = 0.507).

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      Author and article information

      Affiliations
      [1 ] Department of Pharmacology/Hemocenter-FCM, State University of Campinas, SP, Brazil.
      Journal
      Hum Exp Toxicol
      Human & experimental toxicology
      SAGE Publications
      0960-3271
      0960-3271
      Mar 1998
      : 17
      : 3
      9587786 10.1177/096032719801700308

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