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      The Reactivity of Iliac Vascular Strips from Spontaneously Hypertensive and Normotensive Rats

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          Abstract

          Comparison of responses to norepinephrine (NE) and KC1 of iliac arterial strips from spontaneously hypertensive rats (SHR) and three strains of normotensive rats (NR) were made in tissues obtained from 5- to 7- and 15- to 17-week-old animals. The systolic blood pressures of young rats were essentially similar while the 15- to 17-week-old SHR had markedly higher blood pressures than their normotensive counterparts. The contractility and sensitivity of strips to NE from SHR were less than those from NR in both age groups. Relaxation of NE-induced responses in normal physiological or calcium-free solutions was consistently more rapid with SHR tissues. In calcium-free solution, the fast component of responses to NE was smaller in young SHR; no difference in dependence on calcium was seen in tissues from older rats. Differences in KCl-induced responses were seen only in young animals, where reduced contractility and slower relaxation in normal physiological solutions were obtained with strips from SHR. We conclude that the iliac artery from SHR differs intrinsically from those of NR since the differences in responses were evident in young rats prior to the development of stable hypertensive state in the SHR.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 5
          : 246-256
          Affiliations
          Department of Biochemical Pharmacology, School of Pharmacy, State University of New York at Buffalo, Buffalo, N.Y.
          Article
          158254 Blood Vessels 1980;17:246–256
          10.1159/000158254
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Research Paper

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