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Angiotensin-forming enzyme in brain tissue.

Author(s): D Ganten, Joey P. Granger, K Hayduk, R Boucher, Myriam Barbeau, Austin Minnich, J Genest, Ryan M. Brecht

Publication date: 1971-07-02

Keywords: Aldosterone, pharmacology, Angiotensin II, biosynthesis, Animals, Brain Chemistry, Caudate Nucleus, analysis, drug effects, enzymology, Depression, Chemical, Dogs, Progesterone, Renin, Sodium, metabolism, Stimulation, Chemical

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Abstract

A renin-like enzyme is present in brain tissue and is independent of kidney and plasma renin. In the presence of homologous substrate it forms angiotensin. Administration of aldosterone significantly decreases this angiotensinforming enzyme activity, while administration of progesterone markedly enhances it.

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PubMed ID:: 4325865

DOI:: 10.1126/science.173.3991.64

ScienceOpen disciplines: Chemistry

Keywords: Aldosterone,pharmacology,Angiotensin II,biosynthesis,Animals,Brain Chemistry,Caudate Nucleus,analysis,drug effects,enzymology,Depression, Chemical,Dogs,Progesterone,Renin,Sodium,metabolism,Stimulation, Chemical

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ScienceOpen disciplines: Chemistry

Angiotensin-forming enzyme in brain tissue.

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