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      Localisation tubaire et ovarienne d'une malakoplakie: à propos d'un cas et revue de la literature Translated title: Ovarian and tubal localization of a malakoplakia: report of a case and review of literature

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          Abstract

          La malakoplakie est une pathologie inflammatoire rare qui résulte d'un déficit de la fonction phagocytaire macrophagique. Il n'existe pas de symptomatologie spécifique de la maladie mais dépendante de l'organe touché. Nous rapportons un cas rare de malakoplakie annexielle chez une femme de 36 ans qui a été opérée pour suspicion de cancer ovarien et dont le diagnostic de malakoplakie ne s'est fait qu’à l'examen anatomopathologique. La malakoplakie touche essentiellement le tractus urogénital et le diagnostic positif repose seulement sur l'histologie. Le traitement est basé sur l'antibiothérapie et l'exérèse chirurgicale si mauvais état de l'organe atteint.

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          Most cited references 14

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          Malacoplakia: a study of the literature and current concepts of pathogenesis, diagnosis and treatment.

           M Stanton,  W MAXTED (1981)
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            Malacoplakia. Two case reports and a comparison of treatment modalities based on a literature review.

            Malacoplakia is a rare infectious disease that has been almost exclusi vely reported in urology and pathology journals. We studied two cases of malacoplakia that were primarily referred to the department of internal medicine because of fever and abdominal masses. In one patient, malacoplakia was diagnosed in the unusual ovarian location, while in the other patient a large renal mass was found and ciprofloxacin therapy failed because of bacterial resistance. The clinical and radiologic appearance of malacoplakia often mimics that of a malignant tumor. The principal disorder is probably a monocytic-macrophagic bactericidal defect. A definitive diagnosis depends on microscopic detection of Michaelis-Gutmann bodies by means of von Kossa stain. We outlined treatment strategies on the basis of a review of the literature since 1981, which included 140 cases. If possible, immunosuppressive drugs should be stopped. Quinolone antibiotic treatment and surgical excision or incision and drainage lead to the highest cure rates (90% and 81%, respectively). Specific intracellular penetration of quinolone antibiotics is a possible reason for the higher cure rate achieved with these antibiotics. Bethanechol has been suggested to correct the supposed fundamental disturbance by increasing the intrecellular cyclic guanosine monophosphate concentration, but there is still no convincing evidence of its clinical efficacy.
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              Malakoplakia.

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                Author and article information

                Journal
                Pan Afr Med J
                Pan Afr Med J
                PAMJ
                The Pan African Medical Journal
                The African Field Epidemiology Network
                1937-8688
                09 September 2015
                2015
                : 22
                Affiliations
                [1 ]Service de Gynécologie-Obstétrique Maternité des Orangers CHU Ibn Sina, Rabat, Maroc
                Author notes
                [& ]Corresponding author: Ikram Boubess, Service de Gynécologie-Obstétrique Maternité des Orangers CHU Ibn Sina, Rabat, Maroc
                Article
                PAMJ-22-17
                10.11604/pamj.2015.22.17.6561
                4646435
                © Ikram Boubess et al.

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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