Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review.

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Abstract

Levothyroxine (LT4) is a drug with a narrow therapeutic index, applied in small amounts (micrograms), which makes interactions in the absorption phase clinically significant. The main aim of this article was to review and present the latest information on factors that affect the gastrointestinal absorption of this drug.

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Journal

Journal ID (iso-abbrev): Clin Ther

Title: Clinical therapeutics

Publisher: Elsevier BV

ISSN (Electronic): 1879-114X

ISSN (Print): 0149-2918

Publication date (Electronic): Feb 2017

Volume: 39

Issue: 2

Affiliations

[1 ] Pharmacy Department, General Hospital Šibenik, Šibenik, Croatia.

[2 ] Department of Endocrinology, Diabetes and Metabolic Disorders, Clinical Hospital Dubrava, Zagreb, Croatia.

[3 ] Department of Health Ecology, Public Health Brčko DC, Brčko DC, Bosnia and Herzegovina. Electronic address: daniela.amidzic@gmail.com.

[4 ] Department of Paediatrics, Children's Hospital Zagreb, Zagreb, Croatia.

[5 ] Department of Endocrinology, Diabetes and Metabolic Disorders, General Hospital "Sv. Duh," Zagreb, Croatia.

[6 ] Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota.

Article

Publisher Item ID: S0149-2918(17)30038-3

DOI: 10.1016/j.clinthera.2017.01.005

PubMed ID: 28153426

SO-VID: 02da658c-404b-46b8-b0e5-6509133cda98

History

Keywords: GI diseases,levothyroxine,interactions,absorption

Data availability:

Keywords: GI diseases, levothyroxine, interactions, absorption

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