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      Ibuprofen potentiates the in vivo antifungal activity of fluconazole against Candida albicans murine infection.

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          Abstract

          Candida albicans is the most prevalent cause of fungemia worldwide. Its ability to develop resistance in patients receiving azole antifungal therapy is well documented. In a murine model of systemic infection, we show that ibuprofen potentiates fluconazole antifungal activity against a fluconazole-resistant strain, drastically reducing the fungal burden and morbidity. The therapeutic combination of fluconazole with ibuprofen may constitute a new approach for the management of antifungal therapeutics to reverse the resistance conferred by efflux pump overexpression.

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          Author and article information

          Journal
          Antimicrob. Agents Chemother.
          Antimicrobial agents and chemotherapy
          American Society for Microbiology
          1098-6596
          0066-4804
          Jul 2015
          : 59
          : 7
          Affiliations
          [1 ] Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal sqco@med.up.pt.
          [2 ] Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal.
          [3 ] Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital São João, Porto, Portugal.
          [4 ] Department of Microbiology, Faculty of Medicine, University of Porto, Porto, Portugal CINTESIS-Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal Burn Unit, Department of Plastic and Reconstructive Surgery, Hospital São João, Porto, Portugal Department of Microbiology, Hospital São João, Porto, Portugal.
          Article
          AAC.05056-14
          10.1128/AAC.05056-14
          4468673
          25845879
          02da9fd1-7e4c-4763-afa9-787ace0d985e
          History

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