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      Carcinoma de células escamosas de pene Translated title: Squamous cell carcinoma of the penis

      case-report

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          Abstract

          RESUMEN Introducción: El cáncer de pene es una neoplasia maligna poco frecuente en todo el mundo; representa el 1 % de todos los cánceres que afectan a los hombres. Es una neoplasia caracterizada por un proceso proliferativo de células epiteliales, originándose a partir de la piel del prepucio interno o del glande, que se identifica por un crecimiento invasivo y diseminación metastásica temprana a ganglios linfáticos. Objetivo: Exponer la presentación clínica, diagnóstico y tratamiento de un hombre joven con cáncer de pene. Caso clínico: Paciente masculino de 31 años de edad, color de la piel blanca, con antecedentes de salud anterior y de procedencia urbana; que desde hace dos años presenta lesión ulcerosa, descamativa, granulosa en el pene; no dolorosa, con secreciones fétidas y que ha ido aumentando de tamaño. Con la aplicación de anestesia regional espinal se realizó penectomía parcial y se confirmó el diagnóstico de un carcinoma de células escamosas de pene. Conclusiones: El carcinoma de células escamosas de pene es infrecuente en hombres jóvenes y de buen pronóstico si es diagnosticado a tiempo y para cuyo diagnóstico se precisa ser especialmente estricto con los criterios histológicos. La penectomía parcial es el tratamiento de elección de la lesión primaria. El seguimiento de estos pacientes es fundamental para actuar de forma rápida ante la presencia de recidiva o adenopatías metastásicas.

          Translated abstract

          ABSTRACT Introduction : Cancer of the penis is a rare malignant neoplasm worldwide; it represents 1 % of all cancers that affect men. It is a neoplasm characterized by a proliferative process of epithelial cells, originating from the skin of the inner prepuce or glans penis, which is identified by invasive growth and early metastatic spread to lymph nodes. Objective : To expose the clinical presentation, diagnosis and treatment of a young man with penile cancer. Clinical case : Male patient 31 years of age, white skin color, with a history of previous health and urban origin; that for two years has had ulcerative, decamative, granulous lesion on the penis; not painful, with fetid secretions and that has been increasing in size. With the application of regional spinal anesthesia, partial penectomy was performed and the diagnosis of squamous cell carcinoma of the penis was confirmed. Conclusions : Squamous cell carcinoma of the penis is uncommon in young men and has a good prognosis if it is diagnosed early and for whose diagnosis it is necessary to be especially strict with the histological criteria. Partial penectomy is the treatment of choice for the primary lesion. The follow-up of these patients is essential to act quickly in the presence of recurrence or metastatic adenopathies.

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          Most cited references12

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          Case Report: Two Cases of Chemotherapy Refractory Metastatic Penile Squamous Cell Carcinoma With Extreme Durable Response to Pembrolizumab

          Background Penile squamous cell carcinoma (PSCC) is a rare malignancy, and those patients with metastatic disease have limited treatment options. Treatment is largely comprised of platinum-based chemotherapy; however, patients progressing after initial chemotherapy have a median overall survival (OS) of less than 6 months. Based on a high percentage of PD-L1 expression in patients with PSCC, and its biological similarities to other squamous cell carcinomas, we present two patient cases treated with pembrolizumab with extraordinary durable treatment response far beyond treatment with standard therapy. Main Body The first patient is a 64 year old male with PSCC who was treated with neoadjuvant chemotherapy, partial penectomy, and adjuvant radiation prior to developing metastatic disease. He had a high TMB (14 mutations/Mb) and was started on pembrolizumab with a complete response, which has been maintained for 38 months. The second patient is an 85 year old male with PSCC who was treated with partial penectomy and adjuvant chemotherapy and radiation prior to developing metastatic disease. He had positive PD-L1 expression CPS 130) and was started on pembrolizumab with a partial response, which has been maintained for 18 months after starting treatment. Conclusions These two cases of extreme durable response with pembrolizumab (with molecular data including TMB and PD-L1 status) represent a significant clinical benefit in this patient population. With limited treatment options that result in a median OS of less than 6 months, along with the toxicity profile of chemotherapy which may not be tolerated in elderly patients with comorbidities, this survival benefit with pembrolizumab, along with advances in tumor sequencing and clinical trials shows that there is a potentially significant benefit with novel therapies in this patient population.
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            Carcinoma escamoso de pene: comunicación de un caso y revisión de la bibliografía

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              Características Clínicas y Experiencia en el Tratamiento del Cáncer de Pene en el Hospital General San Juan de Dios de Guatemala

                Author and article information

                Journal
                amc
                Revista Archivo Médico de Camagüey
                Arch méd Camagüey
                Universidad de Ciencias Médicas de Camagüey (Camagüey, , Cuba )
                1025-0255
                2023
                : 27
                : e9394
                Affiliations
                [4] Camagüey orgnameUniversidad de Ciencias Médicas orgdiv1Facultad de Tecnología de la Salud orgdiv2Departamento de Imagenología y Radiofísica Médica Cuba
                [3] Camagüey orgnameUniversidad de Ciencias Médicas orgdiv1Hospital Universitario Manuel Ascunce Domenech orgdiv2Servicio de Urología Cuba
                [1] Camagüey orgnameUniversidad de Ciencias Médicas orgdiv1Hospital Universitario Manuel Ascunce Domenech orgdiv2Servicio de Anestesiología y Reanimación Cuba
                [2] Camagüey orgnameUniversidad de Ciencias Médicas orgdiv1Hospital Universitario Manuel Ascunce Domenech orgdiv2Departamento de Anatomía Patológica Cuba
                Article
                S1025-02552023000100018 S1025-0255(23)02700000018
                02ddb00e-560f-4e8c-a60e-a11001694c3a

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 22 January 2023
                : 07 November 2022
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 12, Pages: 0
                Product

                SciELO Cuba

                Categories
                REPORTE DE CASO

                ADULT,NEOPLASIAS DEL PENE/diagnóstico,NEOPLASIAS DEL PENE/cirugía,CARCINOMA DE CÉLULAS ESCAMOSAS,ANESTESIA RAQUIDEA,ADULTO,PENILE NEOPLASMS/ diagnosis,PENILE NEOPLASMS/surgery,CARCINOMA, SQUAMOUS CELL,ANESTHESIA, SPINAL

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