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      Noradrenaline, by Activation of Alpha-1-Adrenoceptors in the Region of the Supraoptic Nucleus, Causes Secretion of Vasopressin in the Unanaesthetized Rat

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          Abstract

          In unanaesthetized rats chronically prepared with venous and intracerebral cannulae, noradrenaline injected into the region of the supraoptic nuclei caused a dose-dependent increase in plasma vasopressin, measured by radioimmunoassay. A similar response was obtained with phenylephrine, but not with either clonidine or isoprenaline. The secretion of vasopressin was not secondary to change in arterial pressure, since similar injections of noradrenaline resulted in a small increase in arterial pressure, measured in the anaesthetized rat. These results suggest that noradrenaline stimulates alpha-1-adrenoceptors, presumably located on vasopressin-secreting neurones, thereby causing these cells to secrete vasopressin into the circulation. Tyramine injections also resulted in a prompt elevation in plasma vasopressin, indicating that endogenous noradrenaline is capable of releasing vasopressin.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1987
          1987
          02 April 2008
          : 45
          : 3
          : 219-226
          Affiliations
          Centre for Neuroscience and Department of Medicine, Flinders University of South Australia, Bedford Park, Australia
          Article
          124729 Neuroendocrinology 1987;45:219–226
          10.1159/000124729
          3031526
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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