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      Potassium-Induced Relaxation as an Indicator of Na +-K + ATPase Activity in Vascular Smooth Muscle

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      Journal of Vascular Research

      S. Karger AG

      Sodium, Potassium, Ouabain, Rat tail artery, Magnesium, Electrogenic pump

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          Abstract

          Helical strips of rat tail artery were observed to relax in response to potassium after contraction induced by 10<sup>–7</sup> g/ml norepinephrine in potassium-free solution. After several minutes of relaxation, the strips showed an abrupt redevelopment of tension. The amplitude of the potassium-induced relaxation was employed as an index of the activity of the electrogenic sodium-potassium pump and hence of the Na<sup>+</sup>-K<sup>+</sup> ATPase. This assumption seemed justified because the observed amplitude of potassium-induced relaxation paralleled known effects of the following variables on Na<sup>+</sup>-K<sup>+</sup> ATPase: (1) intracellular sodium concentration; (2) ouabain administration; (3) magnesium; (4) temperature, and (5) potassium concentration. The relaxation that occurred in response to potassium is suggested to be due to an enhanced Na<sup>+</sup>-K<sup>+</sup> ATPase resulting in increased electrogenic transport of sodium and potassium and, consequently, hyperpolarization. We propose that potassium-induced relaxation of rat tail artery may be used as a functional indicator of Na<sup>+</sup>-K<sup>+</sup> ATPase activity in vascular smooth muscle.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          978-3-8055-2857-3
          978-3-318-02028-1
          1018-1172
          1423-0135
          1978
          1978
          18 September 2008
          : 15
          : 1-3
          : 198-207
          Affiliations
          Department of Physiology, University of Michigan Medical School, Ann Arbor, Mich.
          Article
          158166 Blood Vessels 1978;15:198–207
          10.1159/000158166
          © 1978 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Molecular and Cellular Aspects of Vascular Smooth Muscle in Health and Disease

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