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      Mannheim Carotid Intima-Media Thickness and Plaque Consensus (2004–2006–2011)

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          Abstract

          Intima-media thickness (IMT) provides a surrogate end point of cardiovascular outcomes in clinical trials evaluating the efficacy of cardiovascular risk factor modification. Carotid artery plaque further adds to the cardiovascular risk assessment. It is defined as a focal structure that encroaches into the arterial lumen of at least 0.5 mm or 50% of the surrounding IMT value or demonstrates a thickness >1.5 mm as measured from the media-adventitia interface to the intima-lumen interface. The scientific basis for use of IMT in clinical trials and practice includes ultrasound physics, technical and disease-related principles as well as best practice on the performance, interpretation and documentation of study results. Comparison of IMT results obtained from epidemiological and interventional studies around the world relies on harmonization on approaches to carotid image acquisition and analysis. This updated consensus document delineates further criteria to distinguish early atherosclerotic plaque formation from thickening of IMT. Standardized methods will foster homogenous data collection and analysis, improve the power of randomized clinical trials incorporating IMT and plaque measurements and facilitate the merging of large databases for meta-analyses. IMT results are applied to individual patients as an integrated assessment of cardiovascular risk factors. However, this document recommends against serial monitoring in individual patients.

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          Author and article information

          Journal
          CED
          Cerebrovasc Dis
          10.1159/issn.1015-9770
          Cerebrovascular Diseases
          S. Karger AG
          1015-9770
          1421-9786
          2012
          November 2012
          01 November 2012
          : 34
          : 4
          : 290-296
          Affiliations
          aOperative Unit of Neurology, Jazzolino Hospital, Vibo Valentia, bDepartment of Neurology, S. Giovanni di Dio Hospital, Crotone, cOperative Unit of Neurophysiopathology, Monteluce Hospital and dOperative Unit of Neurology, Città di Castello Hospital, Perugia, eOperative Unit of Neurophysiopathology, S. Martino Hospital, Genoa, fOperative Unit of Neurology, Torrino Hospital, Brindisi, gS. Filippo Neri Hospital and hOperative Unit of Neurovascular Treatment, Department of Neurology and Psychiatry, La Sapienza University, Rome, Italy
          Author notes
          *Prof. P.-J. Touboul, Stroke Center Bichat Hospital, 46, rue Henri-Huchard, FR–75018 Paris (France), E-Mail pjtw@noos.fr
          Article
          343145 Cerebrovasc Dis 2012;34:290–296
          10.1159/000343145
          3760791
          23128470
          03015eed-5fbc-4e92-a11f-a69505b93772
          © 2012 S. Karger AG, Basel

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          Page count
          Figures: 5, Pages: 7
          Categories
          Original Paper

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