Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura.

Khanal, Nabin; Dahal, Sumit; Upadhyay, Smrity; Bhatt, Vijaya Raj; Bierman, Philip J

doi:10.1177/2040620715571076

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Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura.

Author(s): Nabin Khanal ¹ , Sumit Dahal ² , Smrity Upadhyay ¹ , Vijaya Raj Bhatt ³ , Philip J Bierman ⁴

Publication date (Electronic): Jun 2015

Journal: Therapeutic advances in hematology

Publisher: SAGE Publications

Keywords: ADAMTS-13 deficiency, malignant hypertension, plasma exchange, renal failure, thrombocytopenia, thrombotic microangiopathy, thrombotic thrombocytopenic purpura

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Abstract

Malignant hypertension can cause thrombotic microangiopathy (TMA) and the overall presentation may mimic thrombotic thrombocytopenic purpura (TTP). This presents a dilemma of whether or not to initiate plasma exchange. The objective of the study was to determine the clinical and laboratory manifestations of malignant hypertension-induced TMA, and its outcomes.

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Journal ID (iso-abbrev): Ther Adv Hematol

Title: Therapeutic advances in hematology

Publisher: SAGE Publications

ISSN: 2040-6207

ISSN (Print): 2040-6207

Publication date (Electronic): Jun 2015

Volume: 6

Issue: 3

Affiliations

[1 ] Department of Internal Medicine, Creighton University Medical Center, Omaha, Nebraska, USA.

[2 ] Department of Internal Medicine, Interfaith Medical Center, NY, USA.

[3 ] Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, 987680 Nebraska Medical Center, Omaha, NE 68198-7680, USA.

[4 ] Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Article

Publisher Item ID: 10.1177_2040620715571076

DOI: 10.1177/2040620715571076

PMC ID: 4480518

PubMed ID: 26137201

SO-VID: 03030578-aefb-45b0-908a-dcc4761b9235

History

Keywords: thrombotic microangiopathy,thrombotic thrombocytopenic purpura,ADAMTS-13 deficiency,malignant hypertension,plasma exchange,renal failure,thrombocytopenia

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Keywords: thrombotic microangiopathy, thrombotic thrombocytopenic purpura, ADAMTS-13 deficiency, malignant hypertension, plasma exchange, renal failure, thrombocytopenia

Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura.

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Karger: Nephrology

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