Efficacy and safety of certolizumab pegol in pregnant women with uveitis. Recommendations on the management with immunosuppressive and biologic therapies in uveitis during pregnancy.

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Abstract

Clinicians often face the challenge of providing effective and safe therapy for pregnant women with uveitis. Certolizumab pegol (CZP) differs from other anti-TNFα agents due to its limited placental transfer. In this study we assessed the efficacy of CZP in pregnant women with uveitis. We also provided information on outcomes of pregnant women and neonates exposed to CZP.

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Journal

Journal ID (iso-abbrev): Clin Exp Rheumatol

Title: Clinical and experimental rheumatology

Publisher:

ISSN: 0392-856X

ISSN (Print): 0392-856X

Publication date (Electronic): October 31 2020

Volume: 39

Issue: 1

Affiliations

[1 ] Rheumatology and Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain.

[2 ] Clinic Institute of Ophthalmology (ICOF), Hospital Clinic of Barcelona, Spain.

[3 ] Rheumatology, Hospital Universitario de Donostia, San Sebastián, Spain.

[4 ] Rheumatology, Hospital Universitario Txagorritxu, Vitoria-Gasteiz, Spain.

[5 ] Rheumatology, Hospital de Mérida, Spain.

[6 ] Internal Medicine, Hospital Galdakano, Vizcaya, Spain.

[7 ] Rheumatology, Hospital Universitario Río Hortega, Valladolid, Spain.

[8 ] Rheumatology, Hospital General Universitario de Elche, Alicante, Spain.

[9 ] Rheumatology, Hospital Universitario de Badajoz, Spain.

[10 ] Rheumatology, Hospital de Cabueñes, Gijón, Spain.

[11 ] Rheumatology, Hospital General Universitari de Castelló, Castellón de la Plana, Spain.

[12 ] Rheumatology, Hospital Río Carrión, Palencia, Spain.

[13 ] Ophthalmology, Complejo Asistencial Universitario de León, Spain.

[14 ] Ophthalmology, Hospital Universitario Miguel Servet, Zaragoza, Spain.

[15 ] Rheumatology and Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, and University of Cantabria, School of Medicine, Santander, Spain.

[16 ] Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Madrid, Spain.

[17 ] Rheumatology and Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, University of Cantabria, School of Medicine, Santander, Spain, and Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. miguelaggay@hotmail.com.

[18 ] Rheumatology and Ophthalmology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. rblanco@humv.es.

Article

Publisher Item ID: 15180

PubMed ID: 33124565

SO-VID: 03039159-b0fc-4c28-8b4f-f747b3e25133

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