Wenxin Keli diminishes Ca2+ overload induced by hypoxia/reoxygenation in cardiomyocytes through inhibiting INaL and ICaL.

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Abstract

An increase in the late sodium current (INaL ) causes intracellular Na+ overload and subsequently intracellular Ca2+ ([Ca2+ ]i ) overload via the stimulated reverse Na+ -Ca2+ exchange (NCX). Wenxin Keli (WXKL) is an effective antiarrhythmic Chinese herb extract, but the underlying mechanisms are unclear.

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Journal

Journal ID (iso-abbrev): Pacing Clin Electrophysiol

Title: Pacing and clinical electrophysiology : PACE

Publisher: Wiley

ISSN (Electronic): 1540-8159

ISSN (Print): 0147-8389

Publication date (Electronic): Dec 2017

Volume: 40

Issue: 12

Affiliations

[1 ] Cardio-Electrophysiological Research Laboratory, Medical College of Wuhan University of Science and Technology, Wuhan, China.

[2 ] Department of Cardiology, First Hospital, Peking University, Beijing, China.

[3 ] Buchang Cardio-cerebrovascular Hospital, Xian, China.

[4 ] Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Article

DOI: 10.1111/pace.13206

PubMed ID: 28972668

SO-VID: 03102521-b4c2-4245-b46a-ec9d3312aa0c

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Keywords: Wenxin Keli,late sodium current,hypoxia-rexoygenation,cardiomyocyte,calcium overload

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Keywords: Wenxin Keli, late sodium current, hypoxia-rexoygenation, cardiomyocyte, calcium overload

Wenxin Keli diminishes Ca2+ overload induced by hypoxia/reoxygenation in cardiomyocytes through inhibiting INaL and ICaL.

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Abstract

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Herbal Medicines Journal (Herb Med J)

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