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      Calcium and cancer: targeting Ca2+ transport.

      Nature reviews. Cancer

      Antineoplastic Agents, therapeutic use, Apoptosis, Biological Transport, Calcium, physiology, Calcium Channel Blockers, Calcium Channels, Calcium Signaling, Cell Cycle, Cell Movement, Humans, Neoplasms, drug therapy, physiopathology, Neovascularization, Physiologic, Telomerase, drug effects, metabolism, Transcription, Genetic

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          Abstract

          Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?

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          Most cited references 103

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          Cancer. Addiction to oncogenes--the Achilles heal of cancer.

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            An introduction to TRP channels.

            The aim of this review is to provide a basic framework for understanding the function of mammalian transient receptor potential (TRP) channels, particularly as they have been elucidated in heterologous expression systems. Mammalian TRP channel proteins form six-transmembrane (6-TM) cation-permeable channels that may be grouped into six subfamilies on the basis of amino acid sequence homology (TRPC, TRPV, TRPM, TRPA, TRPP, and TRPML). Selected functional properties of TRP channels from each subfamily are summarized in this review. Although a single defining characteristic of TRP channel function has not yet emerged, TRP channels may be generally described as calcium-permeable cation channels with polymodal activation properties. By integrating multiple concomitant stimuli and coupling their activity to downstream cellular signal amplification via calcium permeation and membrane depolarization, TRP channels appear well adapted to function in cellular sensation. Our review of recent literature implicating TRP channels in neuronal growth cone steering suggests that TRPs may function more widely in cellular guidance and chemotaxis. The TRP channel gene family and its nomenclature, the encoded proteins and alternatively spliced variants, and the rapidly expanding pharmacology of TRP channels are summarized in online supplemental material.
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              Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor

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                Author and article information

                Journal
                17585332
                10.1038/nrc2171

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