Blog
About

13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Conductive hearing loss disrupts synaptic and spike adaptation in developing auditory cortex.

      The Journal of neuroscience : the official journal of the Society for Neuroscience

      pathology, Thalamus, physiology, Synapses, Reaction Time, Neurons, Inhibitory Postsynaptic Potentials, In Vitro Techniques, physiopathology, Hearing Loss, Conductive, Gerbillinae, Dose-Response Relationship, Radiation, Disease Models, Animal, Auditory Threshold, Auditory Pathways, growth & development, Auditory Cortex, Animals, Newborn, Animals, Analysis of Variance, Adaptation, Physiological, Action Potentials, methods, Acoustic Stimulation

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although sensorineural hearing loss (SNHL) is known to compromise central auditory structure and function, the impact of milder forms of hearing loss on cellular neurophysiology remains mostly undefined. We induced conductive hearing loss (CHL) in developing gerbils, reared the animals for 8-13 d, and subsequently assessed the temporal features of auditory cortex layer 2/3 pyramidal neurons in a thalamocortical brain slice preparation with whole-cell recordings. Repetitive stimulation of the ventral medial geniculate nucleus (MGv) evoked robust short-term depression of the postsynaptic potentials in control neurons, and this depression increased monotonically at higher stimulation frequencies. In contrast, CHL neurons displayed a faster rate of synaptic depression and a smaller asymptotic amplitude. Moreover, the latency of MGv evoked potentials was consistently longer in CHL neurons for all stimulus rates. A separate assessment of spike frequency adaptation in response to trains of injected current pulses revealed that CHL neurons displayed less adaptation compared with controls, although there was an increase in temporal jitter. For each of these properties, nearly identical findings were observed for SNHL neurons. Together, these data show that CHL significantly alters the temporal properties of auditory cortex synapses and spikes, and this may contribute to processing deficits that attend mild to moderate hearing loss.

          Related collections

          Author and article information

          Journal
          10.1523/JNEUROSCI.1992-07.2007
          17728455

          Comments

          Comment on this article