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      Magnetic Drug Delivery: Where the Field Is Going

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          Abstract

          Targeted delivery of anticancer drugs is considered to be one of the pillars of cancer treatment as it could allow for a better treatment efficiency and less adverse effects. A promising drug delivery approach is magnetic drug targeting which can be realized if a drug delivery vehicle possesses a strong magnetic moment. Here, we discuss different types of magnetic nanomaterials which can be used as magnetic drug delivery vehicles, approaches to magnetic targeted delivery as well as promising strategies for the enhancement of the imaging-guided delivery and the therapeutic action.

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          Advances in targeting the folate receptor in the treatment/imaging of cancers

          The folate receptor (FR) is an important biomarker for many cancers, and its overexpression on tumours can be exploited for targeted therapy, diagnosis and imaging.
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            Clinical applications of magnetic drug targeting.

            Cancer patients often present with localized disease. Yet, surgical eradication or radiation treatment is not always possible or meaningful. Site-directed drug targeting is one way of local or regional antitumor treatment. Magnetically controlled drug targeting is one of the various possibilities of drug targeting. This technology is based on binding established anticancer drugs with ferrofluids that concentrate the drug in the area of interest (tumor site) by means of magnetic fields. Then, the drug desorbs from the ferrofluid and enfolds its mechanism of action. This paper gives the reader an overview of current applications of ferrofluids (magnetic liquids) in conjunction with magnetic fields as they relate to the latest advances in medical applications and in particular to anticancer treatment. Copyright 2000 Academic Press.
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              Multifunctional Bacteria-Driven Microswimmers for Targeted Active Drug Delivery

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                Author and article information

                Contributors
                Journal
                Front Chem
                Front Chem
                Front. Chem.
                Frontiers in Chemistry
                Frontiers Media S.A.
                2296-2646
                11 December 2018
                2018
                : 6
                : 619
                Affiliations
                [1] 1Department of Chemistry, Indiana University , Bloomington, IN, United States
                [2] 2Department of Physics, Faculty of Science, King Abdulaziz University , Jeddah, Saudi Arabia
                [3] 3A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences , Moscow, Russia
                Author notes

                Edited by: Carlos Lodeiro, Universidade Nova de Lisboa, Portugal

                Reviewed by: Anna Roig, Instituto de Ciencia de Materiales de Barcelona (ICMAB), Spain; Paolo Saccardo, Autonomous University of Barcelona, Spain

                *Correspondence: Lyudmila M. Bronstein lybronst@ 123456indiana.edu

                This article was submitted to Nanoscience, a section of the journal Frontiers in Chemistry

                Article
                10.3389/fchem.2018.00619
                6297194
                30619827
                033a5ff9-71af-45d3-bb0c-f78f3918f11b
                Copyright © 2018 Price, Mahmoud, Al-Ghamdi and Bronstein.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 11 September 2018
                : 30 November 2018
                Page count
                Figures: 2, Tables: 0, Equations: 0, References: 69, Pages: 7, Words: 5674
                Categories
                Chemistry
                Mini Review

                magnetic drug delivery,magnetic targeting,theranostics,iron oxide,magnetic implant

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