Denosumab compared to other treatments to prevent or treat osteoporosis in individuals at risk of fracture: a systematic review and meta-analysis.

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Abstract

The aim of this review is to compare the efficacy and safety of denosumab over other treatments for osteoporosis. The results of this study suggest that the safety of denosumab and its efficacy in reducing fractures is not significantly different from bisphosphonates. Denosumab was, however, more effective in increasing bone mineral density.

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Author and article information

Journal

Journal ID (iso-abbrev): Osteoporos Int

Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1433-2965

ISSN (Print): 0937-941X

Publication date (Electronic): September 2016

Volume: 27

Issue: 9

Affiliations

[1 ] Centre de recherche du CHU de Québec (CHUL), 2705, Boulevard Laurier, Québec, Québec, G1V 4G2, Canada. claudia.beaudoin@crchuq.ulaval.ca.

[2 ] Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, Canada. claudia.beaudoin@crchuq.ulaval.ca.

[3 ] Bureau d'information et d'études en santé des populations, Institut national de santé publique du Québec, Québec, Canada. claudia.beaudoin@crchuq.ulaval.ca.

[4 ] Bureau d'information et d'études en santé des populations, Institut national de santé publique du Québec, Québec, Canada.

[5 ] Département de médecine, Faculté de médecine, Université Laval, Québec, Canada.

[6 ] Centre de recherche du CHU de Québec (CHUL), 2705, Boulevard Laurier, Québec, Québec, G1V 4G2, Canada.

[7 ] Département de médecine, Faculté de médecine, Université de Montréal, Montréal, Canada.

[8 ] Département de médecine sociale et préventive, Faculté de médecine, Université Laval, Québec, Canada.

Article

Publisher Item ID: 10.1007/s00198-016-3607-6

DOI: 10.1007/s00198-016-3607-6

PubMed ID: 27120345

SO-VID: 034a4374-3026-4f01-8ddd-2d3c356e9749

History

Keywords: Safety,Efficacy,Denosumab,Bisphosphonates,Treatment,Fracture

Data availability:

Keywords: Safety, Efficacy, Denosumab, Bisphosphonates, Treatment, Fracture

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