17
views
0
recommends
+1 Recommend
1 collections
    0
    shares

      Call for Papers: Sex and Gender in Neurodegenerative Diseases

      Submit here before September 30, 2024

      About Neurodegenerative Diseases: 3.0 Impact Factor I 4.3 CiteScore I 0.695 Scimago Journal & Country Rank (SJR)

      • Record: found
      • Abstract: found
      • Article: found

      Exposure to Medical Radiation during Fetal Life, Childhood and Adolescence and Risk of Brain Tumor in Young Age: Results from The MOBI-Kids Case-Control Study

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background: We explored the association between ionizing radiation (IR) from pre-natal and post-natal radio-diagnostic procedures and brain cancer risk within the MOBI-kids study. Methods: MOBI-kids is an international (Australia, Austria, Canada, France, Germany, Greece, India, Israel, Italy, Japan, Korea, New Zealand, Spain, The Netherlands) case-control study including 899 brain tumor (645 neuroepithelial) cases aged 10–24 years and 1,910 sex-, age-, country-matched controls. Medical radiological history was collected through personal interview. We estimated brain IR dose for each procedure, building a look-up table by age and time period. Lifetime cumulative doses were calculated using 2 and 5 years lags from the diagnostic date. Risk was estimated using conditional logistic regression. Neurological, psychological and genetic conditions were evaluated as potential confounders. The main analyses focused on neuroepithelial tumors. Results: Overall, doses were very low, with a skewed distribution (median 0.02 mGy, maximum 217 mGy). ORs for post-natal exposure were generally below 1. ORs were increased in the highest dose categories both for post and pre-natal exposures: 1.63 (95% CI 0.44–6.00) and 1.55 (0.57–4.23), respectively, based on very small numbers of cases. The change in risk estimates after adjustment for medical conditions was modest. Conclusions: There was little evidence for an association between IR from radio-diagnostic procedures and brain tumor risk in children and adolescents. Though doses were very low, our results suggest a higher risk for pre-natal and early life exposure, in line with current evidence.

          Related collections

          Author and article information

          Journal
          NED
          Neuroepidemiology
          10.1159/issn.0251-5350
          Neuroepidemiology
          S. Karger AG
          0251-5350
          1423-0208
          2020
          July 2020
          20 March 2020
          : 54
          : 4
          : 343-355
          Affiliations
          [_a] aBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain
          [_b] bUniversitat Pompeu Fabra (UPF), Barcelona, Spain
          [_c] cCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
          [_d] dIMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
          [_e] eDepartment of Public Health, School of Medicine, Tokyo Women’s Medical University, Tokyo, Japan
          [_f] fDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
          [_g] gDepartment of Environmental Health, Center for Public Health, Medical University Vienna, Vienna, Austria
          [_h] hMcLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, Ottawa, Ontario, Canada
          [_i] iDepartment of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
          [_j] jOttawa Hospital Research Institute, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada
          [_k] kFrench National Registry of Childhood Solid Tumors, CHRU, Nancy, France
          [_l] lInserm U1153, Center of Research in Epidemiology and StatisticS (CRESS), Paris, France
          [_m] mParis University, Epidemiology of Childhood and Adolescent Cancers Team (EPICEA), Paris, France
          [_n] nInstitute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany
          [_o] oDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece
          [_p] pUnit of Clinical Epidemiology, Karolinska Institute, Stockholm, Sweden
          [_q] qHaematology-Oncology Unit, First Department of Pediatrics, National and Kapodistrian University of Athens, Medical School, “Aghia Sophia” Children’s Hospital, Athens, Greece
          [_r] rCentre for Cancer Epidemiology, Tata Memorial Centre, Mumbai, India
          [_s] sCancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Ramat Gan, Israel
          [_t] tUnit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Italy
          [_u] uUnit of Neuroepidemiology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
          [_v] vDepartment of Preventive Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea
          [_w] wCentre for Public Health Research, Massey University, Wellington, New Zealand
          [_x] xCentro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain
          [_y] yCancer Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid, Spain
          [_z] zDivision Environmental Epidemiology, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
          Author notes
          *Dr. Elisabeth Cardis, ISGlobal, Radiation Programme, Barcelona Biomedical Research Park (PRBB), Doctor Aiguader, 88, ES–08003 Barcelona (Spain), E-Mail elisabeth.cardis@isglobal.org
          Article
          506131 Neuroepidemiology 2020;54:343–355
          10.1159/000506131
          32200380
          0362b7a5-3115-4ec9-a9c0-4c9a39a6254b
          © 2020 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 14 September 2019
          : 20 January 2020
          Page count
          Figures: 2, Tables: 4, Pages: 13
          Categories
          Original Paper

          Geriatric medicine,Neurology,Cardiovascular Medicine,Neurosciences,Clinical Psychology & Psychiatry,Public health
          Epidemiology studies,Children-adolescent health,Brain cancer,Medical radiation,Environmental exposure

          Comments

          Comment on this article