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      Creating a wearable artificial kidney: where are we now?

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          Abstract

          A wearable and, ultimately, an implantable artificial kidney is a long-held aim in the treatment of patients with end-stage renal disease, provided that it would combine continuous blood purification, preventing the fluctuations in the internal environment associated with hemodialysis, while maintaining a high efficiency for removal of uremic toxins. Sorbent and enzyme technology, allowing for the regeneration of dialysis fluid, have played a vital role in the development of present prototypes, although the development of a low-weight regeneration module as well as safety and control issues still need to be solved. Whereas the first human trials with a wearable device have been successfully conducted, there are still many hurdles to overcome before wearable dialysis can be routinely implemented in dialysis practice. Important in this respect are the absence of a safe continuous blood access system and the risk balance between anticoagulation and clotting and regulatory aspects.

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          Author and article information

          Journal
          Expert Rev Med Devices
          Expert review of medical devices
          Informa Healthcare
          1745-2422
          1743-4440
          Jul 2015
          : 12
          : 4
          Affiliations
          [1 ] Department of Internal Medicine, Division of Nephrology, University Hospital Maastricht, Maastricht, The Netherlands.
          Article
          10.1586/17434440.2015.1053466
          26076370

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