Blog
About

21
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Triterpenoid saponins from the roots of Cyathula officinalis and their inhibitory effects on nitric oxide production

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28- O-[ α-L-rhamnopyranosyl-(1→3)- β-D-glucuronopyranosyl-(1→3)- β-D-glucopyranosyl] hederagenin ( 1), was isolated from the roots of Cyathula officinalis. The anti-inflammatory activities of the isolates were evaluated for their inhibitory effects against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages cells. Compounds 2, 4, and 6 exhibited moderate anti-inflammatory activities.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 June 2017
          : 15
          : 6
          : 463-466
          Affiliations
          1State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
          2Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding author: WANG Hao, Tel: 86-25-86185376, Fax: 86-25-85301528; E-mail: wanghao@ 123456cpu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(17)30069-9
          10.1016/S1875-5364(17)30069-9
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National New Drug Innovation Major Project of China
          Award ID: 2012ZX09304005002
          Funded by: Fundamental Research Funds for the Central Universities
          Award ID: JKFP2013003
          Funded by: National Undergraduate Training Program for Innovation and Entrepreneurship
          Award ID: G13031
          This work was supported by the National New Drug Innovation Major Project of China (No. 2012ZX09304005002), the Fundamental Research Funds for the Central Universities (No. JKFP2013003) and National Undergraduate Training Program for Innovation and Entrepreneurship (No. G13031).

          Comments

          Comment on this article