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      Severe Hypertension – Is there a Drug of Choice?

      Nephron

      S. Karger AG

      Hypertension, Treatment, Converting enzyme inhibition, Calcium antagonists

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          Abstract

          Severity of hypertension may be defined in terms of the height of the arterial pressure, or the degree of organ damage present or the resistance to drug therapy. These definitions do not necessarily overlap in the individual case. A variety of drugs is now available for treatment of the severe case however defined, but results of current treatment of such cases in practice have not reduced the risk of stroke or of myocardial infarction to that of the age-and sex-matched normotensive population. Data from which to select drugs with favourable effects on left ventricular hypertrophy, glomerular hyperfiltration or the cerebral circulation are scanty and need amplification. Choice of drug therapy in current circumstances remains empirical, although there are probable advantages in the use of converting enzyme inhibitors or calcium antagonists in the treatment of severe hypertension.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          978-3-8055-4710-9
          978-3-318-01616-1
          1660-8151
          2235-3186
          1987
          1987
          05 December 2008
          : 47
          : Suppl 1
          : 47-50
          Affiliations
          Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford, UK
          Article
          184553 Nephron 1987;47:47–50
          10.1159/000184553
          3696349
          © 1987 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Session II: Types of Hypertension

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