Nephrotic Syndrome During 2-Mercapto-Propionyl-Glycine (Thiola) Therapy

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Abstract

The occurrence of the nephrotic syndrome in 3 patients treated for 1–8 months with 2-mercapto-propionyl-glycine (Thiola) (at doses ranging from 0.750 to 2.000 g/day) is reported. The drug had been administered for chronic active hepatitis in 1 patient and for cystinuria in the remaining patients. Percutaneous renal biopsies, obtained in all patients and examined at light microscopy, immunofluorescence and electron microscopy, showed ‘minimal change’ nephropathy in 2 patients and membranous glomerulonephritis in the 3rd patient. In all patients, complete remission of the nephrotic syndrome and, eventually, disappearance of proteinuria were observed 15–120 days after discontinuation of Thiola. It is suggested that this drug may act either through an antigenie mechanism, akin to that of penicillamine, or through a sensitization mechanism, both of them being able to cause the nephrotic syndrome.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1981

Publication date (Print): 1981

Publication date (Electronic): 02 December 2008

Volume: 28

Issue: 2

Pages: 96-99

Affiliations

Divisione Nefrologia, Istituti Ospitalieri di Verona, Italia; I Cattedra Anatomia Patologica, Università di Roma, Italia

Article

Publisher ID: 182123 Other ID: Nephron 1981;28:96–99

DOI: 10.1159/000182123

SO-VID: 0393c283-9d7d-482b-9a27-eb1b1c409adf

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 18 November 1980

Page count

Pages: 4

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