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      Effect of topical administration of 0.8% nalbuphine on the cornea in dogs after phacoemulsification.

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          Abstract

          It is suggested that topical application of opioids may provide localized analgesia without delay in corneal wound healing. This study was designed to evaluate the effect of topical application of 0.8% nalbuphine on post-operative ocular pain in dogs. Twelve eyes from 11 dogs undergoing phacoemulsification cataract surgery were divided into a nalbuphine group (n=6) and saline group (n=6). Postoperatively, the nalbuphine group received 0.1 ml of topical 0.8% alkalinized nalbuphine (pH 5.6) every 8 hr, and the saline group received 0.1 ml of topical saline (pH 5.9) as a placebo. All dogs received systemic postoperative pain managements with oral tramadol (4 mg/kg) and prednisolone (0.5 mg/kg) every 8 hr. All dogs received pre- and post-ophthalmic examinations. Pain was scored in the dogs using a pain scoring system modified from the University of Melbourne pain scale at 15, 30 and 60 min following the topical treatment on days 1 and 2 (24 and 48 hr after surgery). Eye blink frequency and corneal touch threshold (CTT) were recorded at the same time. There was no statistical difference in the pain score between groups. Significant decreases in CTT, blepharospasm and eye blink frequency were observed after the topical nalbuphine treatment. This indicated that topical application of 0.8% nalbuphine solution can produce a rapid reduction of corneal discomfort in dogs.

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          Author and article information

          Journal
          J. Vet. Med. Sci.
          The Journal of veterinary medical science
          1347-7439
          0916-7250
          2013
          : 75
          : 8
          Affiliations
          [1 ] Department of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, 250-1 Kuo Kuang Road, Taichung 402, Taiwan.
          Article
          DN/JST.JSTAGE/jvms/12-0125
          23708961
          0396367f-cc38-4550-8b83-e3e75dc6d837
          History

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