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      Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.

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          Abstract

          Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play a key role in the progression of head and neck squamous cell carcinoma (HNSCC). On the basis of our preclinical data demonstrating that phosphodiesterase-5 (PDE5) inhibition can modulate these cell populations, we evaluated whether the PDE5 inhibitor tadalafil can revert tumor-induced immunosuppression and promote tumor immunity in patients with HNSCC.

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          Author and article information

          Journal
          Clin. Cancer Res.
          Clinical cancer research : an official journal of the American Association for Cancer Research
          1078-0432
          1078-0432
          Jan 1 2015
          : 21
          : 1
          Affiliations
          [1 ] Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida.
          [2 ] Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida.
          [3 ] Department of Public Health Sciences and Sylvester Biostatistics and Bioinformatics Core Resource, University of Miami, Miller School of Medicine, Miami, Florida.
          [4 ] Department of Pathology, University of Miami, Miller School of Medicine, Miami, Florida.
          [5 ] Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland.
          [6 ] Oncology Department, Johns Hopkins University, Baltimore, Maryland.
          [7 ] Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida. pserafini@med.miami.edu.
          Article
          1078-0432.CCR-14-1711 NIHMS660638
          10.1158/1078-0432.CCR-14-1711
          25320361
          ©2014 American Association for Cancer Research.

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