Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.

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Abstract

Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play a key role in the progression of head and neck squamous cell carcinoma (HNSCC). On the basis of our preclinical data demonstrating that phosphodiesterase-5 (PDE5) inhibition can modulate these cell populations, we evaluated whether the PDE5 inhibitor tadalafil can revert tumor-induced immunosuppression and promote tumor immunity in patients with HNSCC.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Jan 1 2015

Volume: 21

Issue: 1

Affiliations

[1 ] Department of Otolaryngology, University of Miami, Miller School of Medicine, Miami, Florida.

[2 ] Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida.

[3 ] Department of Public Health Sciences and Sylvester Biostatistics and Bioinformatics Core Resource, University of Miami, Miller School of Medicine, Miami, Florida.

[4 ] Department of Pathology, University of Miami, Miller School of Medicine, Miami, Florida.

[5 ] Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, Maryland.

[6 ] Oncology Department, Johns Hopkins University, Baltimore, Maryland.

[7 ] Department of Microbiology and Immunology, University of Miami, Miller School of Medicine, Miami, Florida. pserafini@med.miami.edu.

Article

Publisher Item ID: 1078-0432.CCR-14-1711 Mid ID: NIHMS660638

DOI: 10.1158/1078-0432.CCR-14-1711

PubMed ID: 25320361

SO-VID: 03a7bfae-8f3e-4024-9128-432dd45d25ef

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