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      On the Mechanism of Angiotensin-Induced Proteinuria

      Nephron

      S. Karger AG

      Angiotensin II, Renal hemodynamics, Proteinuria, All-binding

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          Abstract

          To test whether angiotensin (All) induces proteinuria via its effect on renal hemodynamics, or by another mechanism, two experimental approaches were used. In the first, it was found that All was as effective in inducing proteinuria in nephrotic as in intact rats. In all All augmented proteinurias, filtration fraction was increased. These effects plus electrophoretic profiles of All proteinuria in intact rats suggested that hemodynamic changes underly the increased glomΕrular permeability to protein. In the second approach, the All inhibitor, sar-ala-angiotensin, does not itself induce proteinuria or changes in GFR and RPF, but prevented the hemodynamic responses to All and the proteinuric response as well.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1981
          1981
          02 December 2008
          : 27
          : 1
          : 47-50
          Affiliations
          Department .Pof Physiology, CMDNJ-New Jersey Medical School, Newark, N.J.
          Article
          182020 Nephron 1981;27:47–50
          10.1159/000182020
          7219637
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Renal hemodynamics, Angiotensin II, Proteinuria, All-binding

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