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      Two sisters producing anti-U1RNP exhibit serological concordance and clinical discordance.

      1 , ,
      Lupus
      SAGE Publications

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          Abstract

          Two sisters had autoimmune responses to the U1RNP particle that were quantitatively similar and/or identical in molecular characteristics. No other autoantibodies were demonstrable. Both sisters immunoprecipitated only U1RNA, had a reaction of identity in gel diffusion, bound the 68-kDa band in HeLa cell extract in Western blot, and reacted almost equally to a rabbit anti-idiotypic reagent made against either sister's isolated anti-U1RNP Fab fragments. They both carried a DR4 allele, which has been associated with anti-U1RNP production in several studies. While the sisters both had Raynaud's phenomenon, their clinical pictures were otherwise dissimilar. One had a seizure disorder (Ju); the other had polymyositis and features of scleroderma (Je). In sister Ju, Raynaud's phenomenon was manifest for the first time in association with the appearance of precipitating anti-U1RNP.

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          Author and article information

          Journal
          Lupus
          Lupus
          SAGE Publications
          0961-2033
          0961-2033
          Aug 1992
          : 1
          : 4
          Affiliations
          [1 ] Department of Medicine, Oklahoma University Health Sciences Center, Oklahoma Medical Research Foundation, Oklahoma City 73104.
          Article
          10.1177/096120339200100408
          1301988
          03c36b5d-9419-460a-aabf-70a03e37d4ab
          History

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