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      Association of Higher CD4(+) CD25(high) CD127(low) , FoxP3(+) , and IL-2(+) T Cell Frequencies Early After Lung Transplantation With Less Chronic Lung Allograft Dysfunction at Two Years.

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          Abstract

          Regulatory T cells (Treg) can regulate alloantigens and may counteract chronic lung allograft dysfunction (CLAD) in lung transplantation. We analyzed Treg in peripheral blood prospectively and correlated percentages of subpopulations with the incidence of CLAD at 2 years. Among lung-transplanted patients between January 2009 and July 2011, only patients with sufficient Treg measurements were included into the study. Tregs were measured immediately before lung transplantation, at 3 weeks and 3, 6, 12, and 24 months after transplantation and were defined as CD4(+) CD25(high) T cells and further analyzed for CTLA4, CD127, FoxP3, and IL-2 expressions. Between January 2009 and July 2011, 264 patients were transplanted at our institution. Among the 138 (52%) patients included into the study, 31 (22%) developed CLAD within 2 years after transplantation. As soon as 3 weeks after lung transplantation, a statistically significant positive association was detected between Treg frequencies and later absence of CLAD. At the multivariate analysis, increasing frequencies of CD4(+) CD25(high) CD127(low) , CD4(+) CD25(high) FoxP3(+) and CD4(+) CD25(high) IL-2(+) T cells at 3 weeks after lung transplantation emerged as protective factors against development of CLAD at 2 years. In conclusion, higher frequencies of specific Treg subpopulations early after lung transplantation are protective against CLAD development.

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          Author and article information

          Journal
          Am. J. Transplant.
          American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
          Wiley-Blackwell
          1600-6143
          1600-6135
          Jun 2017
          : 17
          : 6
          Affiliations
          [1 ] Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.
          [2 ] Department of Surgery, Munich Lung Transplant Group, Ludwig-Maximilian's University, Munich, Germany.
          [3 ] Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
          Article
          10.1111/ajt.14148
          27931084
          03dcf05f-0a1e-42c0-8355-8bbd4f8a52da

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