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The impact of osteoporosis on health-related quality of life in patients after liver transplantation – a pilot study

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      Liver transplantation (LT) is now a well-established procedure with 5-year survival rates over 70%, and one of its ultimate goals is the improvement of patient health-related quality of life (HRQOL). Osteoporosis remains a serious potential complication of LT, leading to fragility fractures, pain, and functional impairment.


      To assess the degree of osteoporosis and the impact of fragility fractures on HRQOL in patients with chronic liver diseases treated with LT.

      Material and methods

      Twenty-seven patients (14 female, 13 male) at a median period of 3.5 years post LT participated in the study. HRQOL was assessed by Short Form-36 and PBC-40 instruments. Bone mineral density (BMD) in the lumbar spine and hip neck were measured by dual-energy X-ray absorptiometry. Physical activity was assessed by questionnaire. Data on the duration of the liver disease, time from LT, and fragility fractures were also collected.


      As many as 74.1% of the patients had reduced BMD ( t-score < -1.0 SD) in the hip. Mean values of the spine and hip BMD z-scores were -1.1 and -0.9 SD, respectively. Time after LT, percentage of lean tissue, and physical activity were positively associated with BMD. The prevalence of fractures was 48%. We did not find significant differences in age, gender, body composition parameters, physical activity, BMD, and HRQOL scores between the subjects with and without fractures.


      We found a high prevalence of fragility fractures and a decreased BMD in LT recipients. Patients with a history of fractures had similar HRQOL scores to those without fractures.

      Related collections

      Most cited references 38

      • Record: found
      • Abstract: found
      • Article: not found

      The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection.

      A 36-item short-form (SF-36) was constructed to survey health status in the Medical Outcomes Study. The SF-36 was designed for use in clinical practice and research, health policy evaluations, and general population surveys. The SF-36 includes one multi-item scale that assesses eight health concepts: 1) limitations in physical activities because of health problems; 2) limitations in social activities because of physical or emotional problems; 3) limitations in usual role activities because of physical health problems; 4) bodily pain; 5) general mental health (psychological distress and well-being); 6) limitations in usual role activities because of emotional problems; 7) vitality (energy and fatigue); and 8) general health perceptions. The survey was constructed for self-administration by persons 14 years of age and older, and for administration by a trained interviewer in person or by telephone. The history of the development of the SF-36, the origin of specific items, and the logic underlying their selection are summarized. The content and features of the SF-36 are compared with the 20-item Medical Outcomes Study short-form.
        • Record: found
        • Abstract: found
        • Article: not found

        International physical activity questionnaire: 12-country reliability and validity.

        Physical inactivity is a global concern, but diverse physical activity measures in use prevent international comparisons. The International Physical Activity Questionnaire (IPAQ) was developed as an instrument for cross-national monitoring of physical activity and inactivity. Between 1997 and 1998, an International Consensus Group developed four long and four short forms of the IPAQ instruments (administered by telephone interview or self-administration, with two alternate reference periods, either the "last 7 d" or a "usual week" of recalled physical activity). During 2000, 14 centers from 12 countries collected reliability and/or validity data on at least two of the eight IPAQ instruments. Test-retest repeatability was assessed within the same week. Concurrent (inter-method) validity was assessed at the same administration, and criterion IPAQ validity was assessed against the CSA (now MTI) accelerometer. Spearman's correlation coefficients are reported, based on the total reported physical activity. Overall, the IPAQ questionnaires produced repeatable data (Spearman's rho clustered around 0.8), with comparable data from short and long forms. Criterion validity had a median rho of about 0.30, which was comparable to most other self-report validation studies. The "usual week" and "last 7 d" reference periods performed similarly, and the reliability of telephone administration was similar to the self-administered mode. The IPAQ instruments have acceptable measurement properties, at least as good as other established self-reports. Considering the diverse samples in this study, IPAQ has reasonable measurement properties for monitoring population levels of physical activity among 18- to 65-yr-old adults in diverse settings. The short IPAQ form "last 7 d recall" is recommended for national monitoring and the long form for research requiring more detailed assessment.
          • Record: found
          • Abstract: found
          • Article: not found

          The World Health Organization Quality of Life Assessment (WHOQOL): development and general psychometric properties.

           M Power,  B Murphy,  W Kuyken (1998)
          This paper reports on the field testing, empirical derivation and psychometric properties of the World Health Organisation Quality of Life assessment (the WHOQOL). The steps are presented from the development of the initial pilot version of the instrument to the field trial version, the so-called WHOQOL-100. The instrument has been developed collaboratively in a number of centres in diverse cultural settings over several years; data are presented on the performance of the instrument in 15 different settings worldwide.

            Author and article information

            [1 ]Hepatology and Internal Medicine Unit, Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland
            [2 ]Liver Research Laboratories, Pomeranian Medical University, Szczecin, Poland
            [3 ]Department of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland
            [4 ]Department of Environmental Hazard Prevention and Allergology, Medical University of Warsaw, Warsaw, Poland
            [5 ]Department of Hypertension and Internal Medicine, Pomeranian Medical University, Szczecin, Poland
            Author notes
            Address for correspondence: Prof. Tomasz Miazgowski MD, PhD, Department of Hypertension and Internal Medicine, Pomeranian Medical University, 1 Unii Lubelskiej St, 71-252 Szczecin, Poland. phone: +48 91 425 35 50, fax: +48 91 425 35 52. e-mail: miazgowski@
            Prz Gastroenterol
            Prz Gastroenterol
            Przegla̜d Gastroenterologiczny
            Termedia Publishing House
            19 June 2015
            : 10
            : 4
            : 215-221
            4697035 25298 10.5114/pg.2015.52343
            Copyright © 2015 Termedia

            This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

            Original Paper

            liver transplantation, osteoporosis


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