The aim of the present study is to evaluate the application of high rate integrated anaerobic-aerobic/biogranular activated carbon sequencing batch reactor (IAnA-BioGACSBR) to treat raw strong leachate from open dumping of municipal solid waste. The influence of two important and effective independent variables, COD concentrations and volumetric filling rate with GAC, onto the leachate treatment were investigated. Three responses such as TKN, BOD and COD were considered for evaluating the interaction of parameters. The results showed that maximum BOD 5 removal of 98.9% in anaerobic zone and 99% in aerobic zone was obtained at the highest values of COD (~30000 mg/L) and filling ratio (~50%). The highest values of COD removal efficiency were found to be 98.54% and 98%, at COD rate of 10000 mg/L and GAC of 35%, respectively. The highest removal values of TKN was 77.2% and 78.9% in anaerobic and aerobic zone, respectively. Under optimal conditions, compared with the SBR and the GAC-SBR performances, results reveal that the application of the GAC-SBR has shown better effluent characteristics. Based on the results, it can be asserted that the application of the high rate IAnA-BioGACSBR for the treatment of biodegradable landfill leachate was more effective.