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      Photoacoustic-Enabled Self-Guidance in Magnetic-Hyperthermia Fe@Fe3 O4 Nanoparticles for Theranostics In Vivo.

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          Abstract

          Magnetic nanoparticles have gained much interest for theranostics benefited from their intrinsic integration of imaging and therapeutic abilities. Herein, c(RGDyK) peptide PEGylated Fe@Fe3 O4 nanoparticles (RGD-PEG-MNPs) are developed for photoacoustic (PA)-enabled self-guidance in tumor-targeting magnetic hyperthermia therapy in vivo. In the αv β3 -positive U87MG glioblastoma xenograft model, the PA signal of RGD-PEG-MNPs reaches its maximum in the tumor at 6 h after intravenous administration. This signal is enhanced by 2.2-folds compared to that of the preinjection and is also 2.2 times higher than that in the blocking group. It demonstrates the excellent targeting property of RGD-PEG-MNPs. With the guidance of the PA, an effective magnetic hyperthermia to tumor is achieved using RGD-PEG-MNPs.

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          Author and article information

          Journal
          Adv Healthc Mater
          Advanced healthcare materials
          Wiley
          2192-2659
          2192-2640
          May 2018
          : 7
          : 9
          Affiliations
          [1 ] The Key Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China.
          [2 ] Department of Chemistry, Fudan University, Shanghai, 200433, China.
          Article
          10.1002/adhm.201701201
          29356419
          04263858-9cfc-4430-89ff-80edb65c881f
          © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

          Fe@Fe3O4 nanoparticles,PA imaging,in vivo theranostics,magnetic hyperthermia

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