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      Renal and Cardiovascular Effects of Renal Denervation in Conscious Rats after Adenosine Administration and Nitric Oxide Synthase Inhibition

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          Abstract

          The role of renal nerves on renal and cardiovascular responses to adenosine administration and/or acute NO synthase inhibition was investigated. Conscious male Wistar rats with implanted catheters in femoral artery for blood pressure registration, femoral vein for drug infusion and bladder for urine collection were used. Adenosine was applied i.v. (1.0 mg/kg BW bolus) followed by infusion of 0.1 mg/kg·min, and/or nitric oxide synthase inhibition (NOSI) was performed by i.v. administration of 10 mg/kg BW N-Ω-nitro- L-arginine methyl ester (L-NAME) before and 1 week after bilateral renal denervation (BRD). NOSI decreased HR and increased SAP, MAP and DAP both in intact and BRD rats. Baroreflex sensitivity increased in intact and BRD rats. Adenosine did not change HR, blood pressure or baroreflex sensitivity in intact as well as BRD rats. NOSI increased V, VU<sub>Na</sub> and VU<sub>CI</sub> in intact rats but decreased V and did not alter VU<sub>Na</sub> and VU<sub>CI</sub> in BRD rats. Adenosine increased V, VU<sub>CI</sub> and C<sub>cr</sub> in intact rats but did not change renal excretory function in BRD rats. Combined application of adenosine and L-NAME led to a dramatic increase of V, VU<sub>Na</sub>, VU<sub>Cl</sub> and C<sub>cr</sub> in intact rats. However, VU<sub>Na</sub> and VU<sub>CI</sub> in BRD rats were lower as compared to intact rats. Therefore, changes in renal excretory function seen after NOSI are not exclusively the result of pressure diuresis and natriuresis but in some way are dependent on renal nerves. Renal denervation attenuates the renal excretory response to adenosine. Sympathetic nervous system is important in mediating the effects of adenosine and/or NO on renal excretory function. Renal denervation did not change the pattern of baroreflex sensitivity after adenosine and/or L-NAME administration.

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          A multidisciplinary approach to hemodialysis access: Prospective evaluation

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            Effects of Adenosine Receptor Agonists on Efferent Renal Nerve Activity in Anesthetized Rats

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              Author and article information

              Journal
              KBR
              Kidney Blood Press Res
              10.1159/issn.1420-4096
              Kidney and Blood Pressure Research
              S. Karger AG
              1420-4096
              1423-0143
              2002
              2002
              08 November 2002
              : 25
              : 4
              : 217-223
              Affiliations
              Department of Physiology, Medical University, Sofia, Bulgaria
              Article
              66342 Kidney Blood Press Res 2002;25:217–223
              10.1159/000066342
              12424423
              © 2002 S. Karger AG, Basel

              Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

              Page count
              Figures: 2, Tables: 1, References: 30, Pages: 7
              Product
              Self URI (application/pdf): https://www.karger.com/Article/Pdf/66342
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              Original Paper

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