Andria Mousa:
ORCID: http://orcid.org/0000-0001-9406-7481
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: SoftwareRole: ValidationRole: VisualizationRole: Writing
– original draftRole: Writing – review & editing
Abdullah Al-Taiar:
ORCID: http://orcid.org/0000-0001-7421-3381
Role: Data curationRole: ResourcesRole: Writing – review & editing
Nicholas M. Anstey: Role: Data curationRole: ResourcesRole: Writing – review & editing
Cyril Badaut:
ORCID: http://orcid.org/0000-0002-0064-6384
Role: Data curationRole: ResourcesRole: Writing – review & editing
Bridget E. Barber:
ORCID: http://orcid.org/0000-0003-1066-7960
Role: Data curationRole: ResourcesRole: Writing – review & editing
Quique Bassat:
ORCID: http://orcid.org/0000-0003-0875-7596
Role: ConceptualizationRole: Data curationRole: ResourcesRole: Writing – review &
editing
Joseph D. Challenger:
ORCID: http://orcid.org/0000-0001-6029-1733
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Aubrey J. Cunnington:
ORCID: http://orcid.org/0000-0002-1305-3529
Role: ConceptualizationRole: Data curationRole: ResourcesRole: Writing – review &
editing
Dibyadyuti Datta:
ORCID: http://orcid.org/0000-0002-1693-935X
Role: Data curationRole: ResourcesRole: Writing – review & editing
Chris Drakeley:
ORCID: http://orcid.org/0000-0003-4863-075X
Role: Data curationRole: ResourcesRole: Writing – review & editing
Azra C. Ghani:
ORCID: http://orcid.org/0000-0002-0007-4910
Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Victor R. Gordeuk:
ORCID: http://orcid.org/0000-0003-4725-7295
Role: Data curationRole: ResourcesRole: Writing – review & editing
Matthew J. Grigg:
ORCID: http://orcid.org/0000-0001-9914-8352
Role: Data curationRole: ResourcesRole: Writing – review & editing
Pierre Hugo:
ORCID: http://orcid.org/0000-0001-6489-4531
Role: ConceptualizationRole: Writing – review & editing
Chandy C. John:
ORCID: http://orcid.org/0000-0002-1634-1411
Role: Data curationRole: ResourcesRole: Writing – review & editing
Alfredo Mayor:
ORCID: http://orcid.org/0000-0003-3890-2897
Role: Data curationRole: ResourcesRole: Writing – review & editing
Florence Migot-Nabias:
ORCID: http://orcid.org/0000-0001-9982-594X
Role: Data curationRole: ResourcesRole: Writing – review & editing
Robert O. Opoka: Role: Data curationRole: ResourcesRole: Writing – review & editing
Geoffrey Pasvol: Role: Data curationRole: ResourcesRole: Writing – review & editing
Claire Rees:
ORCID: http://orcid.org/0000-0001-5649-7835
Role: Data curationRole: ResourcesRole: Writing – review & editing
Hugh Reyburn: Role: Data curationRole: ResourcesRole: Writing – review & editing
Eleanor M. Riley: Role: Data curationRole: ResourcesRole: Writing – review & editing
Binal N. Shah:
ORCID: http://orcid.org/0000-0001-5169-7301
Role: Data curationRole: ResourcesRole: Writing – review & editing
Antonio Sitoe: Role: Data curationRole: ResourcesRole: Writing – review & editing
Colin J. Sutherland:
ORCID: http://orcid.org/0000-0003-1592-6407
Role: Data curationRole: ResourcesRole: Writing – review & editing
Philip E. Thuma:
ORCID: http://orcid.org/0000-0002-1508-4409
Role: Data curationRole: ResourcesRole: Writing – review & editing
Stefan A. Unger:
ORCID: http://orcid.org/0000-0001-7089-5063
Role: Data curationRole: ResourcesRole: Writing – review & editing
Firmine Viwami: Role: Data curationRole: ResourcesRole: Writing – review & editing
Michael Walther: Role: Data curationRole: ResourcesRole: Writing – review & editing
Christopher J. M. Whitty: Role: Data curationRole: ResourcesRole: Writing – review & editing
Timothy William: Role: Data curationRole: ResourcesRole: Writing – review & editing
Lucy C. Okell:
ORCID: http://orcid.org/0000-0001-7202-6873
Role: ConceptualizationRole: InvestigationRole: MethodologyRole: Project administrationRole:
SupervisionRole: Writing – review & editing
Lorenz von Seidlein: Role: Academic Editor
Journal ID (nlm-ta): PLoS Med
Journal ID (iso-abbrev): PLoS Med
Journal ID (publisher-id): plos
Journal ID (pmc): plosmed
Title:
PLoS Medicine
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1549-1277
ISSN
(Electronic):
1549-1676
Publication date
(Electronic):
19
October
2020
Publication date Collection:
October
2020
Volume: 17
Issue: 10
Electronic Location Identifier: e1003359
Affiliations
[1
]
MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease
Epidemiology, Imperial College London, London, United Kingdom
[2
]
School of Community & Environmental Health, College of Health Sciences, Old Dominion
University, Norfolk, Virginia, United States of America
[3
]
Global Health Division, Menzies School of Health Research and Charles Darwin University,
Darwin, Northern Territory, Australia
[4
]
Division of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia
[5
]
Unité de Biothérapie Infectieuse et Immunité, Institut de Recherche Biomédicale des
Armées, Brétigny-sur-Orge, France
[6
]
Unité des Virus Emergents (UVE: Aix-Marseille Univ—IRD 190—Inserm 1207—IHU Méditerranée
Infection), Marseille, France
[7
]
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
[8
]
ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain
[9
]
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique
[10
]
ICREA, Barcelona, Spain
[11
]
Pediatric Infectious Diseases Unit, Pediatrics Department, Hospital Sant Joan de Déu
(University of Barcelona), Barcelona, Spain
[12
]
Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP),
Madrid, Spain
[13
]
Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial
College London, United Kingdom
[14
]
Ryan White Center for Pediatric Infectious Disease and Global Health, Department of
Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States
of America
[15
]
Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine,
London, United Kingdom
[16
]
Sickle Cell Center, Department of Medicine, University of Illinois at Chicago, Chicago,
Illinois, United States of America
[17
]
Medicines for Malaria Venture, Geneva, Switzerland
[18
]
Université de Paris, MERIT, IRD, Paris, France
[19
]
Department of Paediatrics and Child Health, Makerere University School of Medicine,
Kampala, Uganda
[20
]
Imperial College London, Department of Life Sciences, London, United Kingdom
[21
]
Centre for Global Public Health, Institute of Population Health Sciences, Barts &
The London School of Medicine & Dentistry, London, United Kingdom
[22
]
Institute of Immunology and Infection Research, School of Biological Sciences, University
of Edinburgh, Edinburgh, United Kingdom
[23
]
Macha Research Trust, Choma, Zambia
[24
]
Department of Child Life and Health, University of Edinburgh, United Kingdom
[25
]
Department of Respiratory Medicine, Royal Hospital for Sick Children, Edinburgh, United
Kingdom
[26
]
Institut de Recherche Clinique du Bénin (IRCB), Cotonou, Benin
[27
]
Medical Research Council Unit, Fajara, The Gambia at the London School of Hygiene
and Tropical Medicine, Fajara, The Gambia
[28
]
Infectious Diseases Society Sabah-Menzies School of Health Research Clinical Research
Unit, Kota Kinabalu, Sabah, Malaysia
[29
]
Gleneagles Hospital, Kota Kinabalu, Sabah, Malaysia
Mahidol-Oxford Tropical Medicine Research Unit, THAILAND
Author notes
I have read the journal's policy and the authors of this manuscript have the following
competing interests: PH works for Medicines for Malaria Venture (MMV), which has a
Research Collaboration Agreement in place with Imperial College. LCO declares grant
funding from the World Health Organization, the Bill and Melinda Gates Foundation,
and Medicines for Malaria Venture.
[¤]
Current address: Untere Grabenstraße, Leutkirch, Germany.
Author information
Article
Publisher ID:
PMEDICINE-D-20-00452
DOI: 10.1371/journal.pmed.1003359
PMC ID: 7571702
PubMed ID: 33075101
SO-VID: 04331382-305b-496d-a242-de31c6f14bb1
Copyright © © 2020 Mousa et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: G98669
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9406-7481
Andria Mousa
Funded by: UK Medical Research Council and Department for International Development
Award ID: MR/R015600/1
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9406-7481
Andria Mousa
Funded by: UK Royal Society Dorothy Hodgkin fellowship
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7202-6873
Lucy C. Okell
Funded by: funder-id http://dx.doi.org/10.13039/501100004167, Medicines for Malaria Venture;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7202-6873
Lucy C. Okell
Funded by: funder-id http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7202-6873
Lucy C. Okell
Funded by: UK Medical Research Council and Department for International Development
Award ID: MR/R015600/1
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7202-6873
Lucy C. Okell
Funded by: UK Medical Research Council and Department for International Development
Award ID: MR/R015600/1
Award Recipient
:
ORCID: http://orcid.org/0000-0002-0007-4910
Azra C. Ghani
Funded by: UK Medical Research Council and Department for International Development
Award ID: MR/R015600/1
Award Recipient
:
ORCID: http://orcid.org/0000-0001-6029-1733
Joseph D. Challenger
Funded by: National Health and Medical Research Council of Australia
Award Recipient
:
Nicholas M. Anstey
Funded by: National Health and Medical Research Council of Australia
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9914-8352
Matthew J. Grigg
Funded by: Spanish Agency for International Development (AECID)
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0875-7596
Quique Bassat
Funded by: Spanish Agency for International Development (AECID)
Award Recipient
:
ORCID: http://orcid.org/0000-0003-3890-2897
Alfredo Mayor
Funded by: National Institutes of Health (Fogarty Institute)
Award ID: R21 TW-006794
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1634-1411
Chandy C. John
Funded by: National Institute of Neurological Disorders and Stroke and the Fogarty International
Center
Award ID: R01NS055349 and D43 NS078280
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1634-1411
Chandy C. John
Funded by: National Institute of Health
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1508-4409
Philip E. Thuma
Funded by: UK Medical Research Council
Award ID: G0701427
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1305-3529
Aubrey J. Cunnington
Funded by: Medical Research Council (MRC) and the UK Department for International Development
(DFID)
Award ID: MR/L006529/1
Award Recipient
:
ORCID: http://orcid.org/0000-0002-1305-3529
Aubrey J. Cunnington
A.Mo. is supported by the UK Medical Research Council (Grant number: G98669,
https://mrc.ukri.org/). LCO acknowledges funding from a UK Royal Society Dorothy Hodgkin fellowship, Medicines
for Malaria Venture, and the Bill & Melinda Gates Foundation. A.Mo., LCO, ACG, and
JDC acknowledge joint Centre funding from the UK Medical Research Council and DFID
under the MRC/DFID Concordat agreement and that is also part of the EDCTP2 programme
supported by the European Union (MR/R015600/1). NMA and MJG are supported by the National
Health and Medical Research Council of Australia (Fellowships 11355820 and 1138860;
Program Grants 1037304 and 1132975). A.Ma. and QB acknowledge ISGlobal, which is a
member of the CERCA Programme (Generalitat de Catalunya,
http://cerca.cat/en/suma/). This research is part of ISGlobal’s Program on the Molecular Mechanisms of Malaria,
which is partially supported by the Fundación Ramón Areces. A.Ma., QB, and AS also
acknowledge the Manhiça Health Research Centre (CISM), which is supported by the Government
of Mozambique and the Spanish Agency for International Development (AECID). A.Ma.
is supported by the Departament d’Universitats i Recerca de la Generalitat de Catalunya,
Agència de Gestió d’Ajuts Universitaris i de Recerca (2017SGR664). For the studies
conducted in Uganda, CCJ acknowledges the National Institutes of Health (Fogarty Institute
grant R21 TW-006794), the National Institute of Neurological Disorders and Stroke,
and the Fogarty International Center (grants R01NS055349 and D43 NS078280). For the
study conducted in Macha, Zambia, VRG acknowledges the National Institute of Allergy
and Infectious Diseases at the National Institutes of Health (grants 1 R01 AI44857
and AI051306); the National Heart, Lung, and Blood Institute and the Office of Research
on Minority Health at the National Institutes of Health (grant UH1-HL03679); and the
National Institute of Research Resources, Howard University General Clinical Research
Center (grant MO1-RR10284). PET received salary support from the NIH/NIAID grant 1
R01 A144857 that funded the study conducted in Macha, Zambia. AJC was supported by
the Medical Research Council (MRC) and the UK Department for International Development
(DFID) under the MRC/DFID Concordat agreement that is also part of the EDCTP2 program
supported by the European Union [MR/L006529/1 and G0701427]. ER, CD, and HR acknowledge
funding from the UK Medical Research Council and DFID under the MRC/DFID Concordat
agreement (grant reference number G9901439) for the studies in North-eastern Tanzania.
For the study conducted in Benin, FMN, CB, and FV acknowledge the French Agence Nationale
de la Recherche (project RESAs, ANR-08-MIE-031). The funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Parasitic Diseases
Subject:
Malaria
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Tropical Diseases
Subject:
Malaria
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Parasitic Diseases
Subject:
Malaria
Subject:
Cerebral Malaria
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Tropical Diseases
Subject:
Malaria
Subject:
Cerebral Malaria
Subject:
Medicine and Health Sciences
Subject:
Health Care
Subject:
Health Care Facilities
Subject:
Medicine and Health Sciences
Subject:
Clinical Medicine
Subject:
Signs and Symptoms
Subject:
Fevers
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Anemia
Subject:
Medicine and Health Sciences
Subject:
Pharmacology
Subject:
Drugs
Subject:
Antimalarials
Subject:
Medicine and Health Sciences
Subject:
Epidemiology
Subject:
Medical Risk Factors
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Clinical Laboratory Sciences
Subject:
Transfusion Medicine
Subject:
Blood Transfusion
Subject:
Medicine and Health Sciences
Subject:
Hematology
Subject:
Transfusion Medicine
Subject:
Blood Transfusion