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Simultaneous HPLC determination of multiple components in a commercial cosmetic cream
October 1998
October 1998
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Abstract
A high-performance liquid chromatographic method for the simultaneous determination
of magnesium ascorbyl phosphate (I), imidazolidinylurea (II), a mixture of methyl-(III),
ethyl-(IV), propyl-(V), butyl-(VI) parabens dissolved in phenoxyethanol, and ascorbyl
palmitate (VII), was studied by using a cyano-propyl column and a methanol gradient
at 220 and 240 nm. Calibration curves were found to be linear in the 0.05-5 mg ml(-1)
range (compounds I, II, VII) and 0.9-160 mg ml(-1) (compounds III-VI). Linear regression
analysis of the data demonstrates the efficacy of the method in terms of precision
and accuracy. An extraction method is developed and validated in order to apply this
chromatographic method to a commercial cosmetic cream. The precision of this method,
calculated as the relative standard deviation (RSD) of the recoveries (1.57-2.21%)
was excellent for all compounds I-VII.