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      Antihyperglycemic, antihyperlipidemic and antioxidant effects of standard ethanol extract of Bombax ceiba leaves in high-fat-diet- and streptozotocin-induced Type 2 diabetic rats

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          Abstract

          The present study aimed at exploring the therapeutic potential of standard extract of Bombax ceiba L. leaves (BCE) in type 2 diabetic mellitus (T2DM). Oral administration of BCE at doses of 70, 140, and 280 mg·kg −1, to the normal rats and the high-fat-diet- and streptozotocin-induced T2DM rats were carried out. Effects of BCE on blood glucose, body weight, and a range of serum biochemical parameters were tested, and histopathological observation of pancreatic tissues was also performed. HPLC-ESI-Q/TOF-MS/MS analysis indicated that the chemical composition of BCE mainly contained mangiferin, isoorientin, vitexin, isomangiferin, isovitexin, quercetin hexoside, 2′-trans- O-cumaroyl mangiferin, and nigricanside. BCE caused a significant decrease in the concentrations of fasting blood glucose, glycosylated hemoglobin, total cholesterol, triglyceride, low density lipoprotein-cholesterol, serum insulin, and malondialdehyde, and increases in oral glucose tolerance, high density lipoprotein-cholesterol, and superoxide dismutase in the T2DM model rats. Moreover, considerable pancreatic β-cells protection effect and stimulation of insulin secretion from the remaining pancreatic β-cells could be observed after BCE treatment. The results indicated that BCE exhibited an excellent hypoglycemic activity, and alleviated dyslipidemia which is associated with T2DM. Antioxidant activity and protecting pancreatic β-cells are the possible mechanisms involved in anti-diabetic activity of BCE.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 March 2017
          : 15
          : 3
          : 168-177
          Affiliations
          1State Key Laboratory of Natural Medicines, Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 210009, China
          2Anhui Key Laboratory of Modernized Chinese Materia Medica, Anhui University of Traditional Chinese Medicine, Hefei 230012, China
          3Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding authors: LIU Bao-Lin, Tel: 86-25-86185127, Fax: 86-25-86185292, E-mail: zhongyao440@ 123456163.com ; QIN Min-Jian, Tel: 86-25-86185130, Fax: 86-25-85301528, E-mail: minjianqin@ 123456163.com

          ΔCo-first author

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(17)30033-X
          10.1016/S1875-5364(17)30033-X
          28411685
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

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