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      Drug Design, Development and Therapy (submit here)

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      Is Open Access

      Synthesis of a vanadyl (IV) folate complex for the treatment of diabetes: spectroscopic, structural, and biological characterization


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          This study aimed to design a compound with folic acid (FAH 2) and vanadyl (IV) for use in the treatment of diabetes.

          Materials and methods

          A novel vanadyl (IV) FAH 2 complex was synthesized and characterized [(FA 2−)(VO 2+)]⋅3H 2O. The speculated structure of this folate complex was determined using physicochemical techniques including microanalytical analysis, conductivity studies, spectroscopic examination, magnetic measurements, thermogravimetric analyses, and morphological X-ray powder diffraction, and scanning and transmission electron microscopies. The anti-diabetic therapeutic potential of the complexes was tested in a 30-day streptozotocin-induced diabetes rat model.


          The conductivity test of the complex implied electrolyte behavior. The spectroscopic assessments of the isolated dark yellow solid complex revealed that FAH 2 acts as a bidentate ligand. The coordination process with two vanadyl (IV) ions occurred through the deprotonation of both carboxyl groups of FAH 2 in a regular square pyramid arrangement at a 2(FA) 2−: 2(VO) 2+ molar ratio. XRD, SEM, and TEM analyses revealed the complex crystalline nature of the complex. Treating diabetic rats with vanadyl (IV) FAH 2 complex significantly improved many biological parameters relevant to diabetes pathology with minimal toxicity.


          The data generated in this study indicate that the synthesized vanadyl (IV) folate complex acts as a model of anti-diabetic agent.

          Most cited references38

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          Kinetic Parameters from Thermogravimetric Data

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            The use of conductivity measurements in organic solvents for the characterisation of coordination compounds

            W.J. Geary (1971)
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              Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination

              G. Deacon (1980)

                Author and article information

                Drug Des Devel Ther
                Drug Des Devel Ther
                Drug Design, Development and Therapy
                Drug Design, Development and Therapy
                Dove Medical Press
                30 April 2019
                : 13
                : 1409-1420
                [1 ]Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia, anaglah@ 123456ksu.edu.sa
                [2 ]Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, Cairo 12622, Egypt, anaglah@ 123456ksu.edu.sa
                [3 ]Chemistry Department, Faculty of Science, Taif University, Taif 21974, Saudi Arabia
                [4 ]Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
                [5 ]Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
                [6 ]Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia
                Author notes
                Correspondence: Ahmed M Naglah, Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia, Email anaglah@ 123456ksu.edu.sa
                © 2019 Naglah et al. This work is published and licensed by Dove Medical Press Limited

                The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

                Original Research

                Pharmacology & Pharmaceutical medicine
                diabetes,vanadyl,folic acid,spectroscopic,streptozotocin,vitamin b9


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