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      Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer.

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          Abstract

          A method for enumerating circulating tumor cells (CTC) has received regulatory clearance. The primary objective of this prospective study was to establish the relationship between posttreatment CTC count and overall survival (OS) in castration-resistant prostate cancer (CRPC). Secondary objectives included determining the prognostic utility of CTC measurement before initiating therapy, and the relationship of CTC to prostate-specific antigen (PSA) changes and OS at these and other time points.

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          Author and article information

          Journal
          Clin Cancer Res
          Clinical cancer research : an official journal of the American Association for Cancer Research
          American Association for Cancer Research (AACR)
          1078-0432
          1078-0432
          Oct 01 2008
          : 14
          : 19
          Affiliations
          [1 ] Section of Medicine, Institute of Cancer Research, Royal Marsden Hospital, Downs Road, Sutton, Surrey, United Kingdom. jdebono@icr.ac.uk
          Article
          14/19/6302
          10.1158/1078-0432.CCR-08-0872
          18829513
          04606ef5-dfd9-4d50-a70c-620b04db851c
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