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      Evaluation of Valaciclovir Dosage Reduction in Continuous Ambulatory Peritoneal Dialysis Patients

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          In continuous ambulatory peritoneal dialysis (CAPD) patients, acyclovir-induced neurotoxicity is reported to be associated with high serum drug levels even when following the recommended reduced doses for this renal failure population. In view of the high oral bioavailability of valaciclovir (the L-valyl ester of acyclovir) the risk of neurotoxicity becomes more prominent. The present study was conducted in 12 CAPD patients who were administered a single oral dose of 500 mg valaciclovir. Acyclovir was analyzed by high-performance liquid chromatography. Relative pharmacokinetic parameters were estimated based on acyclovir concentrations at 8, 12 and 24 h post-dose. High inter-patient variations were observed with acyclovir apparent total clearance 7.238 ± 4 l/h and half-life (T<sub>1/2</sub>) 22.27 ± 16.82 h. However, dosage simulations confirmed supratherapeutic acyclovir concentrations for all participants when following the recommended dose of 1,000 mg valaciclovir/24 h for varicella zoster infections.

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          Author and article information

          S. Karger AG
          May 2002
          02 May 2002
          : 91
          : 1
          : 164-166
          aSchool of Pharmacy, University of London, UK; Renal Units of bUniversity Hospital of Alexandroupolis and cLaiko General Hospital, Athens, Greece
          57621 Nephron 2002;91:164–166
          © 2002 S. Karger AG, Basel

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          Page count
          Tables: 2, References: 6, Pages: 3
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/57621
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