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      Histamine Stimulates Progesterone Synthesis and Cyclic Adenosine 3′,5′-Monophosphate Accumulation in Isolated Preovulatory Rat Follicles

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          Abstract

          The effect of histamine on progesterone synthesis and cyclic adenosine 3’,5’-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H<sub>2</sub>-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H<sub>1</sub>-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H<sub>2</sub>-agonist, 4-methyΓhistamine, but not the H<sub>1</sub>-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H<sub>2</sub>-receptor with cAMP acting as secondary intracellular messenger.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1987
          1987
          02 April 2008
          : 46
          : 1
          : 69-74
          Affiliations
          Department of Obstetrics and Gynecology at Helsingborg and Lund, Department of Physiology, University of Gothenburg, Departments of Histology and Anatomy, University of Lund, Sweden
          Article
          124798 Neuroendocrinology 1987;46:69–74
          10.1159/000124798
          2441309
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 6
          Categories
          Original Paper

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