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      Histamine Stimulates Progesterone Synthesis and Cyclic Adenosine 3′,5′-Monophosphate Accumulation in Isolated Preovulatory Rat Follicles

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          The effect of histamine on progesterone synthesis and cyclic adenosine 3’,5’-monophosphate (cAMP) accumulation was studied in superfused and incubated follicles dissected free from immature rats treated with pregnant mare serum gonadotrophin (PMSG). Histamine, like LH, increased the progesterone synthesis, but to a smaller extent. The H<sub>2</sub>-antagonist, cimetidine, inhibited completely the histamine-induced progesterone increase while the H<sub>1</sub>-antagonist, pyrilamine, as well as propranolol and atropine did not affect the initial response but modified its duration. The specific H<sub>2</sub>-agonist, 4-methyΓhistamine, but not the H<sub>1</sub>-agonist, 2-methylhistamine, mimicked the effect of histamine on progesterone synthesis. In the presence of the phosphodiesterase inhibitor, IBMX, histamine increased tissue levels of cAMP. These results suggest that histamine stimulates progesterone synthesis via the H<sub>2</sub>-receptor with cAMP acting as secondary intracellular messenger.

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          S. Karger AG
          02 April 2008
          : 46
          : 1
          : 69-74
          Department of Obstetrics and Gynecology at Helsingborg and Lund, Department of Physiology, University of Gothenburg, Departments of Histology and Anatomy, University of Lund, Sweden
          124798 Neuroendocrinology 1987;46:69–74
          © 1987 S. Karger AG, Basel

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          Pages: 6
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