Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway.

Zheng, Guirong; Shen, Zhichun; Chen, Hongning; Liu, Jian; Jiang, Kai; Fan, Lulu; Jia, Lee; Shao, Jingwei

doi:10.1016/j.biopha.2017.03.091

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Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway.

Author(s): Guirong Zheng ¹ , Zhichun Shen ¹ , Hongning Chen ¹ , Jian Liu ¹ , Kai Jiang ¹ , Lulu Fan ¹ , Lee Jia ¹ , Jingwei Shao ²

Publication date (Electronic): Jun 2017

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Publisher: Elsevier BV

Keywords: Invasion, Metapristone, Metastasis, Migration, Non-small cell lung cancer, Proliferation

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Abstract

Metastasis is the key phase of cancer progression that characterizes a more advanced stage and a poorer prognosis. The majority of cancer fatalities occur as a consequence of metastasis.

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Journal ID (iso-abbrev): Biomed. Pharmacother.

Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Publisher: Elsevier BV

ISSN (Electronic): 1950-6007

ISSN (Print): 0753-3322

Publication date (Electronic): Jun 2017

Volume: 90

Affiliations

[1 ] Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China.

[2 ] Cancer Metastasis Alert and Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China. Electronic address: shaojingwei@fzu.edu.cn.

Article

Publisher Item ID: S0753-3322(17)31160-5

DOI: 10.1016/j.biopha.2017.03.091

PubMed ID: 28391165

SO-VID: 047ce6a0-6994-4fb4-a76f-9d4a0fdf20eb

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Keywords: Invasion,Metapristone,Metastasis,Migration,Non-small cell lung cancer,Proliferation

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Keywords: Invasion, Metapristone, Metastasis, Migration, Non-small cell lung cancer, Proliferation

Metapristone suppresses non-small cell lung cancer proliferation and metastasis via modulating RAS/RAF/MEK/MAPK signaling pathway.

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