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      Hypertriglyceridemia and Lipoprotein Lipase Activity in Experimental Uremia

      , ,

      Nephron

      S. Karger AG

      Uremia, Lipoprotein lipase, Hypertriglyceridemia

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          Abstract

          The relationship between changes in tissue lipoprotein lipase (LPL) activity and triglyceride (TG) concentration has been studied in chronically uremic rats. Uremic rats had a 6-fold increase in BUN and 75% rise in TG levels associated with a 50% reduction in adipose tissue heparin-releasable LPL activity. However, total LPL activity of adipose tissue and muscle was not significantly decreased. Furthermore, there was no significant correlation between the rise in plasma TG concentration seen in uremic rats and the reduction in heparin-releasable adipose tissue LPL activity. These data suggest that the TG removal defect associated with chronic uremia is not a simple function of a decrease in LPL activity.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 30
          : 3
          : 274-278
          Affiliations
          Department of Medicine, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Palo Alto, Calif., USA
          Article
          182490 Nephron 1982;30:274–278
          10.1159/000182490
          7099342
          © 1982 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hypertriglyceridemia, Uremia, Lipoprotein lipase

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