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      Betacellulin: a mitogen from pancreatic beta cell tumors.

      Science (New York, N.Y.)
      3T3 Cells, Amino Acid Sequence, Animals, Base Sequence, Betacellulin, Cell Division, drug effects, Cells, Cultured, DNA Replication, Endothelium, Vascular, cytology, Epidermal Growth Factor, pharmacology, Growth Substances, genetics, isolation & purification, Humans, Intercellular Signaling Peptides and Proteins, Islets of Langerhans, physiopathology, Kinetics, Mice, Molecular Sequence Data, Muscle, Smooth, Vascular, Oligodeoxyribonucleotides, Pancreatic Neoplasms, Pigment Epithelium of Eye, Polymerase Chain Reaction, methods, Protein Precursors, Rats, Receptor, Epidermal Growth Factor, metabolism, Recombinant Proteins, Sequence Homology, Amino Acid, Thymidine, Transforming Growth Factor alpha

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          Abstract

          Betacellulin, a member of the epidermal growth factor family, has been identified in the conditioned medium of cell lines derived from mouse pancreatic beta cell tumors. Betacellulin is a 32-kilodalton glycoprotein that appears to be processed from a larger transmembrane precursor by proteolytic cleavage. The carboxyl-terminal domain of betacellulin has 50 percent sequence similarity with that of rat transforming growth factor alpha. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

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