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      In vivo burn imaging using Mueller optical coherence tomography

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          Abstract

          We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. In vivo burn imaging was demonstrated on porcine skin at different stages of the wound healing process, where porcine skin was used because of its similarity to the human skin. Thermally damaged region was clearly localized in the depth-resolved phase retardation image extracted from the measured Jones matrix. The burn areas in the OCT images agreed well with the histology. By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system’s potential for in vivo burn-depth determination.

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          Author and article information

          Journal
          101137103
          29989
          Opt Express
          Opt Express
          Optics express
          1094-4087
          12 January 2020
          07 July 2008
          28 January 2020
          : 16
          : 14
          : 10279-10284
          Affiliations
          [1 ]Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843-3120
          [2 ]Current address: General Electric Global Research Center, K1 5C36, 1 Research Circle, Niskayuna, NY 12309
          [3 ]Current address: Bascom Palmer Eye Institute, University of Miami, 206 McKnight Building (Vision Research), 1638 N.W. 10th Avenue, Miami, FL 33136
          [4 ]Current address: Applied Optics Techniques Group, TEISA Department, University of Cantabria, Av. Castros s/n, 39005 Santander, Spain
          [5 ]Department of Pathobiology, Texas A&M University, College Station, TX 77843-5547
          [6 ]Current address: Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, Campus Box 1097, One Brookings Drive, St. Louis, MO 63130-4899
          Author notes
          [* ]Corresponding author: LHWang@ 123456biomed.wustl.edu
          Article
          PMC6986309 PMC6986309 6986309 nihpa1067736
          10.1364/oe.16.010279
          6986309
          18607436
          04945608-5c6d-4ea4-9d18-e84bbfef161b
          History
          Categories
          Article

          (170.4500) Optical coherence tomography,(170.3880) Medical and biological imaging,(260.1440) Birefringence,(260.5430) Polarization,(290.7050) Turbid media,(170.1650) Coherence imaging

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