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      Cyclic AMP and Calcium in the Transduction of Hypothalamic Neurohormone Action in Human Pituitary Tumors

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          Abstract

          Although hypothalamic neurohormones were originally identified on the basis of their ability to influence hormone release from the target cells, it is at present clear that these agents are involved in the control of several biological processes that include cell proliferation and differentiation as well as hyperplasia and neoplastic transformation. Hypothalamic neurohormones bind specific receptors belonging to the G-protein-coupled receptor superfamily to generate intracellular effectors, in particular cAMP and calcium. Several in vivo and in vitro studies suggest the presence of functional and/or structural alterations in the receptor/effector molecules involved in the transduction of hypothalamic neurohormone action in the pituitary. The present study reports the frequent presence in pituitary tumors of cellular alterations that result in amplification of stimulatory signals, particularly activation of the cAMP-dependent pathway, and reduction of inhibitory inputs, both events having possible implications in tumor formation and/or progression.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6504-2
          978-3-318-01928-5
          1663-2818
          1663-2826
          1997
          1997
          09 December 2008
          : 47
          : 4-6
          : 235-239
          Affiliations
          Institute of Endocrine Sciences, Ospedale Maggiore IRCCS, University of Milan and Italian Auxological Center IRCCS, Milan, Italy
          Article
          185469 Horm Res 1997;47:235–239
          10.1159/000185469
          9167957
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Recent Progress on the Molecular Aspects of Endocrine Tumors: Clinical Implications

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