1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Ectopic thyroid gland located on the L4 vertebral body : A case report

      case-report

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Rationale:

          The prevalence of ectopic thyroid is extremely low, with the condition observed in approximately 1 in 100,000 to 300,000 people. Thyroid gland ectopia develops as a result of the presence of developmental abnormalities during the migration of the thyroid anlage from the floor of the primitive foregut to its final position in the neck. Ectopic thyroid tissue is commonly observed in the lingual region, but can also present in other head and neck regions, as well as regions located at a large distance from the neck.

          Patient concerns:

          A 67-year-old woman who had experienced left lumbago and leg pain was transferred to our hospital following the worsening of her lumbago-related symptoms in the 2 months preceding her presentation. Seven years ago, the patient had recurrent lumbago and leg pain without obvious inducement, and visited a local clinic for treatment. The severity of her symptoms fluctuated; their intensity increased after participation in activities and decreased after rest.

          Diagnoses:

          The patient was diagnosed as having an ectopic thyroid gland that was located on the L4 vertebral body.

          Interventions:

          The patient chose to undergo surgery, with supportive care, following tumor discovery.

          Outcomes:

          After surgical treatment, the degree of lumbar spinal stenosis improved, and the patient's clinical symptoms were alleviated.

          Lessons:

          Clinically, ectopic goiter is diagnosed through radionuclide thyroid imaging, ultrasound examination, computed tomography, magnetic resonance imaging, and biopsy pathology. However, the imaging manifestations in this case were atypical, leading to greater diagnostic difficulties. A conclusion was finally reached based on pathology.

          Related collections

          Most cited references7

          • Record: found
          • Abstract: found
          • Article: not found

          Morphological, diagnostic and surgical features of ectopic thyroid gland: a review of literature.

          Ectopic thyroid tissue remains a rare developmental abnormality involving defective or aberrant embryogenesis of the thyroid gland during its passage from the floor of the primitive foregut to its usual final position in pre-tracheal region of the neck. Its specific prevalence accounts about 1 case per 100.000-300.000 persons and one in 4.000-8.000 patients with thyroid disease show this condition. The cause of this defect is not fully known. Despite genetic factors have been associated with thyroid gland morphogenesis and differentiation, just recently some mutation has been associated with human thyroid ectopy. Lingual region in the most common site of thyroid ectopy but ectopic thyroid tissue were found in other head and neck locations. Nevertheless, aberrant ectopic thyroid tissue has been found in other places distant from the neck region. Ectopic tissue is affected by different pathological changes that occur in the normal eutopic thyroid. Patients may present insidiously or as an emergency. Diagnostic management of thyroid ectopy is performed by radionuclide thyroid imaging, ultrasonography, CT scan, MRI, biopsy and thyroid function tests. Asymptomatic euthyroid patients with ectopic thyroid do not usually require therapy but are kept under observation. For those with symptoms, treatment depends on size of the gland, nature of symptoms, thyroid function status and histological findings. Surgical excision is often required as treatment for this condition.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Ectopic thyroid: etiology, pathology and management.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A mouse model demonstrates a multigenic origin of congenital hypothyroidism.

              Congenital hypothyroidism with thyroid dysgenesis (TD) is a frequent human condition characterized by elevated levels of TSH in response to reduced thyroid hormone levels. Congenital hypothyroidism is a genetically heterogeneous disease. In the majority of cases studied, no causative mutations have been identified and very often the disease does not show a Mendelian transmission. However, in approximately 5% of cases, it can be a consequence of mutations in genes encoding the TSH receptor or the transcription factors TITF1, FOXE1, or PAX8. We report here that in mouse models, the combination of partial deficiencies in the Titf1 and Pax8 genes results in an overt TD phenotype that is absent in either of the singly deficient, heterozygous mice. The disease is characterized by a small thyroid gland, elevated levels of TSH, reduced thyroglobulin biosynthesis, and high occurrence of hemiagenesis. The observed phenotype is strain specific, and the pattern of transmission indicates that at least two other genes, in addition to Titf1 and Pax8, are necessary to generate the condition. These results show that TD can be of multigenic origin in mice and strongly suggest that a similar pathogenic mechanism may be observed in humans.
                Bookmark

                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Lippincott Williams & Wilkins (Hagerstown, MD )
                0025-7974
                1536-5964
                15 January 2021
                15 January 2021
                : 100
                : 2
                : e24042
                Affiliations
                Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University.
                Author notes
                []Correspondence: Wenbin Zheng, Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou, 515000, Guangdong Province, China (e-mail: hwenb@ 123456126.com ).
                Author information
                http://orcid.org/0000-0002-2619-0709
                http://orcid.org/0000-0002-1750-4999
                Article
                MD-D-20-02172 24042
                10.1097/MD.0000000000024042
                7808474
                33466154
                04a0cc15-cd95-479a-b7c9-797e10cfd1f6
                Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

                History
                : 13 March 2020
                : 6 August 2020
                : 7 December 2020
                Funding
                Funded by: National Natural Science Foundation of China
                Award ID: 81571627
                Award Recipient : WenBin Zheng
                Funded by: Natural Science Foundation of Guangdong Province, China
                Award ID: 2014A030313481
                Award Recipient : WenBin Zheng
                Categories
                6800
                Research Article
                Clinical Case Report
                Custom metadata
                TRUE

                ectopic thyroid,lumbar spine,magnetic resonance imaging,pet/ computed tomography

                Comments

                Comment on this article