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The Vitamin E Derivative, ESeroS-GS, Attenuates Renal Ischemia-Reperfusion Injury in Rats
Hironori Koga ,
Satoshi Hagiwara ,
Hideto Mei ,
Nozomi Hiraoka ,
Jyunya Kusaka ,
Koji Goto ,
Kenji Kashima ,
Takayuki Noguchi
July 2012
July 2012
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Abstract
Acute kidney injury (AKI), which occurs during renal transplantation and cardiovascular
surgery, is a major clinical problem associated with high mortality, and has limited
treatment options. Anti-inflammation therapy has been suggested to improve the course
and outcome of AKI. In this study, we hypothesized that ESeroS-GS, a vitamin E derivative,
inhibits cytokine production and prevents renal ischemia-reperfusion (I/R) injury
in rats.