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      The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden

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          Abstract

          We evaluated a structured education- and exercise-based self-management program for patients with knee or hip osteoarthritis (OA), using a registry-based study of data from 44,634 patients taken from the Swedish “Better Management of Patients with Osteoarthritis” registry. Outcome measures included a numeric rating scale (NRS), EuroQol five dimension scale (EQ-5D), Arthritis self-efficacy scale (ASES-pain and ASES-other symptoms), pain frequency, any use of OA medication, desire for surgery, fear–avoidance behavior, physical activity, and sick leave were reported at baseline, 3 and 12 month. Changes in scale variables were analyzed using general linear models for repeated measures and changes in binary variables by McNamara’s test. All analyses were stratified by joint. At the 3-month follow-up, patients with knee (n = 30686) and hip (n = 13948) OA reported significant improvements in the NRS-pain, the EQ-5D index, the ASES-other symptoms, and ASES-pain scores with standardized effect size (ES) ranges for patients with knee OA of 0.25–0.57 and hip OA of 0.15–0.39. Significantly fewer patients reported pain more than once weekly, took OA medication, desired surgery, showed fear–avoidance behavior, and were physically inactive. At the 12-month follow-up, patients with knee (n = 21647) and hip (n = 8898) OA reported significant improvements in NRS-pain, EQ-5D index, and a decrease in ASES-other symptoms and ASES-pain scores with an ES for patients with knee OA of –0.04 to 0.43 and hip OA of –0.18 to 0.22. Significantly fewer patients reported daily pain, desired surgery (for hip OA), reported fear–avoidance behavior, and reported sick leave. Following these interventions, patients with knee and hip OA experienced significant reductions in symptoms and decreased willingness to undergo surgery, while using less OA medication and taking less sick leave. The results indicate that offering this program as the first-line treatment for OA patients may reduce the burden of this disease.

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          Most cited references26

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          The validity of pain intensity measures: what do the NRS, VAS, VRS, and FPS-R measure?

          The Numerical Rating Scale (NRS), Visual Analogue Scale (VAS), Verbal Rating Scale (VRS), and Faces Pain Scale-Revised (FPS-R) are valid measures of pain intensity. However, ratings on these measures may be influenced by factors other than pain intensity. The purpose of this study was to evaluate the influence of non-pain intensity factors on the pain intensity scales. We administered measures of pain intensity (NRS, VAS, VRS, FPS-R), pain unpleasantness, catastrophizing, depressive symptoms, and pain interference to 101 individuals with chronic lower back or knee pain. Correlation analyses examined the associations among the pain intensity scales, and regression analyses evaluated the contributions of the non-pain intensity factors (depressive symptoms, and pain unpleasantness, catastrophizing, and interference) to the VAS, VRS, and FPS-R ratings, while controlling for NRS, age, and gender. Although the NRS, VAS, VRS, FPR-S, scales were strongly associated with one another, supporting their validity as measures of pain intensity, regression analyses showed that the VRS also reflected pain interference, the FPS-R also reflected pain unpleasantness, and the VAS was not associated with any of the additional non-pain intensity factors when controlling for NRS, age, and gender. The VAS appears to be most similar to the NRS and less influenced by non-pain intensity factors than the VRS or FPS-R. Although the VRS and FPS-R ratings both reflect pain intensity, they also contain additional information about pain interference and pain unpleasantness, respectively. These findings should be kept in mind when selecting pain measures and interpreting the results of research studies using these scales. The influence of pain interference and pain unpleasantness on VRS and FPS-R, respectively should be kept in mind when selecting pain measures and interpreting the results of research studies using these scales.
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            Current and future impact of osteoarthritis on health care: a population-based study with projections to year 2032.

            To estimate the current and future (to year 2032) impact of osteoarthritis (OA) health care seeking.
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              The numeric rating scale for clinical pain measurement: a ratio measure?

              The Numeric Rating Scale (NRS-11) has been widely used clinically for the assessment of pain. Its use for clinical research is controversial. Reports differ as to whether or not the NRS-11 should be treated as a ratio pain measurement tool. This study compared the NRS-11 to a ratio measure for pain assessment: the visual analog scale (VAS). Simultaneous pain measurements using these 2 scales were compared in clinical situations commonly encountered in a tertiary community hospital. Whereas linear relationships were noted in laboring patients and in postoperative patients with thoracic or abdominal incisions during cough, no such correlations were noted for the same postoperative patients at rest or for postoperative orthopedic patients. The NRS-11 should not be considered to be interchangeable with the VAS. Its use for clinical research should be limited to situations where it has specifically demonstrated linear properties.
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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: SoftwareRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: MethodologyRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                19 September 2019
                2019
                : 14
                : 9
                : e0222657
                Affiliations
                [1 ] Department of Clinical Sciences Lund, Ortopedics, Lund University, Lund, Sweden
                [2 ] Department of Health Sciences, Division of Physiotherapy, Lund University, Lund, Sweden
                University of Tasmania, AUSTRALIA
                Author notes

                Competing Interests: Thérése Jönsson is a member of the steering committee of the BOA registry, for which she does not receive any compensation. Leif Dahlberg is the co-founder and Chief Medical Officer of Joint Academy, a company which provides digital non-surgical treatment for patients with hip and knee osteoarthritis. Leif Dahlberg also owns stocks in, is a board member of, and is a paid part-time consultant of Joint Academy. Joint Academy has otherwise not supported this work financially. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no patents, products in development, or marketed products to declare.

                Author information
                http://orcid.org/0000-0002-4854-4707
                Article
                PONE-D-19-10495
                10.1371/journal.pone.0222657
                6752869
                31536554
                04ab0151-c817-4330-bd48-1bfa03728cfa
                © 2019 Jönsson et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 15 April 2019
                : 3 September 2019
                Page count
                Figures: 3, Tables: 5, Pages: 14
                Funding
                This study was supported by a grant awarded to LED from Governmental Funding of Clinical Research within the National Health Service (grant number: ALFSKANE-429831; https://ansok.med.lu.se/sbs/lunds_mf/minsida/login/enkel). Leif Dahlberg is a co-founder and paid employee of Joint Academy. The specific role of this author is articulated in the 'author contributions' section. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Rheumatology
                Arthritis
                Osteoarthritis
                Biology and Life Sciences
                Anatomy
                Musculoskeletal System
                Pelvis
                Hip
                Medicine and Health Sciences
                Anatomy
                Musculoskeletal System
                Pelvis
                Hip
                Biology and Life Sciences
                Anatomy
                Musculoskeletal System
                Body Limbs
                Legs
                Knees
                Medicine and Health Sciences
                Anatomy
                Musculoskeletal System
                Body Limbs
                Legs
                Knees
                Biology and Life Sciences
                Anatomy
                Musculoskeletal System
                Skeletal Joints
                Knee Joints
                Medicine and Health Sciences
                Anatomy
                Musculoskeletal System
                Skeletal Joints
                Knee Joints
                Medicine and Health Sciences
                Health Care
                Patients
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                People and places
                Geographical locations
                Europe
                European Union
                Sweden
                Medicine and Health Sciences
                Public and Occupational Health
                Physical Activity
                Custom metadata
                Data used for the study is governed by Västra Götalandsregionen. The authors are not allowed to share the data. The data are available from Registercentrum, Västra Götalandsregionen (contact via; boa@ 123456registercentrum.se ) for researchers who meet the criteria for access to confidential data according to Swedish law.

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