Advances in research on tumor microenvironment of hepatocellular carcinoma

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Abstract

Highlights

Chinese and Western medicine have different understandings of the tumor microenvironment and different treatment methods.

Editor’s Summary

The concept of the tumor microenvironment has been widely accepted. In the theory of Chinese and Western medicine, the concept of tumor microenvironment is similar, but there are still differences. Tumor treatment strategies for tumor microenvironment are receiving increasing attention.

Abstract

Modern medical research on cancer shows that hepatocellular carcinoma (HCC) is related to tumor microenvironment. Studying the relationship between tumor microenvironment and HCC can be used as a new research direction to provide more strategies and ideas for the prevention and treatment of HCC. This article describes the characteristics of tumor microenvironment, cytokines, related signaling pathways, the occurrence and development of traditional Chinese medicine and HCC, and treatment-related knowledge.

Most cited references 41

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Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

Oscar Yeung, Chung Mau Lo, Chang Ling … (2015)

The roles of alternatively activated (M2) macrophages on pro-tumour phenotypes have been well documented in many cancers except hepatocellular carcinoma (HCC). Considering their close relationship with chronic tissue injuries as well as enhanced tumour invasiveness and growth, we aimed to investigate the direct effects of M2 macrophages on HCC.

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Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.

X. Wu, Xiang-Ming Lao, Feng Li … (2013)

Defects in natural killer (NK) cell functions are necessary for tumor immune escape, but their underlying regulatory mechanisms in human cancers remain largely unknown. Here we show, in detailed studies of NK cells in 294 untreated patients with hepatocellular carcinoma (HCC), that accumulation of functional NK cells in HCC tissues could predict improved survival of patients. However, in patients with advanced-stage HCC, NK cells were significantly decreased in number with impaired tumor necrosis factor alpha (TNF-α) and interferon-gamma (IFN-γ) production. High infiltration of peritumoral stroma monocytes/macrophages was positively correlated with impaired functional activities of NK cells in intratumoral areas. Further kinetic experiments revealed that soon after exposure to tumor-derived monocytes, NK cells underwent a rapid, transient activation, but then they became exhausted, and eventually died. The monocytes from HCC tissues, but not from nontumoral liver, strongly express CD48 proteins; and such monocyte-induced NK cell dysfunction was markedly attenuated by blocking CD48 receptor 2B4 on NK cells, but not by blockade of NKG2D and NKp30. These data reveal that human NK cells are regulated by a fine-tuned collaborative action between different types of immune cells, which may reflect a novel immune-escape mechanism by which tumors dynamically regulate their functions at distinct tumor microenvironments. Copyright © 2012 American Association for the Study of Liver Diseases.

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A change of strategy in the war on cancer.

Robert Gatenby (2009)

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Author and article information

Contributors

Yang Zhu

Journal

Journal ID (nlm-ta): TMR

Title: TMR Cancer

Publisher: TMR Publishing Group Editorial Board (Cockle Bay Rd, Auckland, New Zealand, 2014 )

ISSN (Electronic): 2538-015X

Publication date Collection: 3 March 2019

Publication date (Electronic): 3 March 2019

Volume: 2

Issue: 1

Pages: 143-150

Affiliations

[1-2538-015X-2-1-143] ¹Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China.

Author notes

*Correspondence: Zhu Yang, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China. E-mail: yangzhu6402@ 123456sina.com .

Article

Publisher ID: 2538-015X-2-1-143

DOI: 10.12032/TMRC201800046

SO-VID: 04af3043-b4df-43ca-abaf-c79e26070ccb

License:

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

History

Date accepted : 10 December 2018

Funding

National Natural Science Foundation of China (81673862)

Science and Technology Support Program of Guizhou Province (Social Development Research) (Qiankehe SY [2014] 3026)

High-level Innovative Talents Training Program of Guizhou Province (100 levels) (Qiankehe (2016)4032)

Guizhou Yangzhu “Traditional Chinese Medicine Oncology” graduate tutor studio (Qian Jiaoyanhe GZS [2016]08).

Advances in research on tumor microenvironment of hepatocellular carcinoma

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Abstract

Highlights

Editor’s Summary

Abstract

Most cited references 41

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma.

Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactions.

A change of strategy in the war on cancer.

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Author notes

Article

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