11
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Effects of Intraventricular Infusions of Norepinephrine and Dopamine on LH Release and Ovulation in the Rabbit

      research-article

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The infusion of 50 µg norepinephrine (NE) into the third ventricle of the brain was found to be highly effective in stimulating the release of an ovulatory surge of LH from the pituitary gland in estrogen-primed rabbits. Intraventricular dopamine (D), in dosages of 5 and 50 µg, was not only completely ineffective in inducing ovulation, but the higher dosage actually blocked the ovulatory effect of NE, often for a month or more after infusion. In experimentts in which LH was measured by radioimmunoassay, intraventricular NE stimulated a marked rise in LH starting within minutes, peaking at 2 h and returning to pre-infusion levels by 6 h. No rise in serum LH was observed following the intraventricular infusion of D. Both dosages of D were quite effective in blocking LH output in response to NE infused 2 h later, and the 50- µg dosage of D generally prevented any rise in serum LH concentration for some weeks after the infusion of intraventricular NE. The results are consistent with the hypothesis that a noradrenergic synapse is functional in hypothalamic mechanisms activating the release of pituitary LH.

          Related collections

          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1974
          1974
          25 March 2008
          : 15
          : 6
          : 328-337
          Affiliations
          Department of Anatomy and Brain Research Institute, University of California School of Medicine, Los Angeles, Calif., and VA Hospital, Long Beach, Calif.
          Article
          122323 Neuroendocrinology 1974;15:328–337
          10.1159/000122323
          4437718
          04afcd5e-a518-47a7-8986-64048c22d69e
          © 1974 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 08 January 1974
          : 15 February 1974
          Page count
          Pages: 10
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Norepinephrine,LH release,Third cerebral ventricle,Ovulation,Rabbit,Dopamine

          Comments

          Comment on this article