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      Somatic generation of antibody diversity

      Nature
      Springer Science and Business Media LLC

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          Abstract

          In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.

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          Most cited references104

          • Record: found
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          The somatic generation of immune recognition.

          N K Jerne (1970)
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            Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways.

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              THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION.

              N K Jerne (1955)
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                Author and article information

                Journal
                Nature
                Nature
                Springer Science and Business Media LLC
                0028-0836
                1476-4687
                April 1983
                April 1983
                : 302
                : 5909
                : 575-581
                Article
                10.1038/302575a0
                6300689
                04b15553-a351-48a6-ad79-08037c47e5bb
                © 1983

                http://www.springer.com/tdm

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