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      Finding community structure in very large networks

      , ,
      Physical Review E
      American Physical Society (APS)

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          A comprehensive two-hybrid analysis to explore the yeast protein interactome.

          Protein-protein interactions play crucial roles in the execution of various biological functions. Accordingly, their comprehensive description would contribute considerably to the functional interpretation of fully sequenced genomes, which are flooded with novel genes of unpredictable functions. We previously developed a system to examine two-hybrid interactions in all possible combinations between the approximately 6,000 proteins of the budding yeast Saccharomyces cerevisiae. Here we have completed the comprehensive analysis using this system to identify 4,549 two-hybrid interactions among 3,278 proteins. Unexpectedly, these data do not largely overlap with those obtained by the other project [Uetz, P., et al. (2000) Nature (London) 403, 623-627] and hence have substantially expanded our knowledge on the protein interaction space or interactome of the yeast. Cumulative connection of these binary interactions generates a single huge network linking the vast majority of the proteins. Bioinformatics-aided selection of biologically relevant interactions highlights various intriguing subnetworks. They include, for instance, the one that had successfully foreseen the involvement of a novel protein in spindle pole body function as well as the one that may uncover a hitherto unidentified multiprotein complex potentially participating in the process of vesicular transport. Our data would thus significantly expand and improve the protein interaction map for the exploration of genome functions that eventually leads to thorough understanding of the cell as a molecular system.
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            NETWORKS OF SCIENTIFIC PAPERS.

            D. Price (1965)
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              An Efficient Heuristic Procedure for Partitioning Graphs

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                Author and article information

                Journal
                PLEEE8
                Physical Review E
                Phys. Rev. E
                American Physical Society (APS)
                1539-3755
                1550-2376
                December 2004
                December 6 2004
                : 70
                : 6
                Article
                10.1103/PhysRevE.70.066111
                15697438
                04b30925-dde0-47c7-8c97-7488ce1ddcf1
                © 2004

                http://link.aps.org/licenses/aps-default-license

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